| 熊汉忠 胡克 翁光明 张剑波 张福瑜.纳洛酮治疗慢性阻塞性肺病合并II型呼吸衰竭患者临床疗效研究[J].现代生物医学进展英文版,2015,15(27):5263-5267. |
| 纳洛酮治疗慢性阻塞性肺病合并II型呼吸衰竭患者临床疗效研究 |
| Study Clinical Curative Effect in Patients with ChronicObstructive Pulmonary Disease Complicated with Type IIRespiratory Failure after Naloxone Treatment |
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| DOI： |
| 中文关键词: 纳洛酮 慢性阻塞性肺病 血清降钙素原 炎症因子 |
| 英文关键词: Nnaloxone Chronic obstructive pulmonary disease Procalcitonin Inflammatory factor |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨纳洛酮治疗慢性阻塞性肺病合并II型呼吸衰竭患者血清降钙素原、炎症因子的改变及临床疗效。方法：收集2013
年5 月至2014 年9 月来我院治疗的COPD合并II 型呼吸衰竭患者60 例，根据治疗方法不同随机分为对照组和观察组，对照组
给与常规治疗，观察组在常规治疗的基础上给与纳洛酮治疗。记录两组患者在治疗前后静脉血PaCO2、PaO2的变化以及临床疗
效。采用Elisa 法检测两组患者在治疗前后血清PCT、TNF-琢、IL-6 含量的变化，并用RT-PCR 法检测两组患者在治疗前后血清
PCT、TNF-琢、IL-6 DNA 的改变。结果：观察组患者在治疗前静脉血PaCO2的值为81.3± 9.4 mmHg，治疗后下降为45.4± 5.3
mmHg，PaO2由49.6± 3.9 mmHg 上升至81.3± 5.9 mmHg，均优于对照组，与对照组比较差异有统计学意义（P＜0.05）；临床总有
效率为85.7%，高于对照组的68%，且差异有统计学意义（P＜ 0.05）。ELISA 检测结果显示，两组患者在治疗后，血清PCT，CRP、
IL-6 含量均显著下降，且观察组下降程度高于对照组，RT-PCR 检测结果与ELISA检测结果相一致。结论：纳洛酮治疗COPD 合
并II型呼吸衰竭的临床疗效显著，能有效的提高PaO2，降低PaCO2，且能有效的减缓炎症反应的加重。 |
| 英文摘要: |
| Objective:To investigate the changes of procalcitonin, serum inflammatory factors and clinical curative effect in
patients with chronic obstructive pulmonary disease complicated with type II respiratory failure after naloxone treatment.Methods:60
patients with COPD and type II respiratory failure who were treated in our hospital from May 2010 to May 2014 were selected and
randomly divided into the observation group and the control group according to the different methods. The patients in the control group
were treated with the conventional method, while the patients in the observation group were treated with the naloxone besides of the
conventional method. Then the changes of PaCO2 and PaO2 in the venous blood of patients in the two groups were observed and
compared before and after the treatment. The ELISA method was used to detect the changes of PCT, TNF-alpha and IL-6 in serum, and the
RT-PCR method was used to detect the changes of PCT, TNF-alpha and IL-6 in terms of DNA of patients in the two groups before and after
the treatment.Results:The observation group patients before treatment of venous blood PaCO2 value of 81.3 ± 9.4 mmHg, and decreased
after the treatment was 45.4± 5.3 mmHg, PaO2 increased from49.6± 3.9 mmHg to 81.3± 5.9 mmHg, were better than the control group,
there was statistically significant difference compared with the control group (P<0.05); The clinical total effective rate was 85.7%, higher
than the 68%in the control group, and the difference was statistically significant (P<0.05). ELISA test results showed that the patients in
the two groups after treatment, serum PCT, CRP, IL-6 content decreased significantly, and the observation group decreased significantly
higher than that of control group, RT-PCR results were consistent with the ELISA detection.Conclusion:The curative effect of naloxone
in the treatment of COPD with type II respiratory failure was significant, which could effectively improve the PaO2, reduced PaCO2, and
could effectively reduce the inflammation reaction. |
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