于美婷 刘彬 王凤军 赵楠 丁查文.瑞舒伐他汀对OX-LDL诱导的人脐静脉内皮细胞PPAR-gamma表达的影响[J].现代生物医学进展英文版,2015,15(25):4956-4959. |
瑞舒伐他汀对OX-LDL诱导的人脐静脉内皮细胞PPAR-gamma表达的影响 |
Effect of Rosuvastatin on PPAR-gamma in Human UmbilicalVein Endothelial Cells |
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DOI: |
中文关键词: 瑞舒伐他汀 动脉粥样硬化 PPAR-gamma OX-LDL |
英文关键词: Rosuvastatin Atherogenesis PPAR-gamma OX-LDL |
基金项目:黑龙江省自然科学基金项目(D201167) |
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中文摘要: |
目的:探讨经氧化低密度脂蛋白(OX-LDL)刺激后,人脐静脉内皮细胞(PPAR-gamma)表达的变化,以及瑞舒伐他汀对动脉粥样硬
化的影响。方法:将实验标本随机分为2 组,分为(OX-LDL)刺激组、瑞舒伐他汀干预组。应用RT-PCR及Western blot 技术,观察
OX-LDL 诱导的人脐静脉内皮细胞PPAR-gamma表达情况及瑞舒伐他汀对人脐静脉内皮细胞PPAR-gamma及浓度依赖的方式降低了人脐静脉内皮细胞PPAR-gamma的表达;2)瑞舒伐他汀可以逆转OX-LDL 对人脐静脉内细胞的影响
并可能与甲羟戊酸有关。结论:OX-LDL可降低人脐静脉内皮细胞PPAR-gamma的表达。瑞舒伐他汀可以抑制OX-LDL诱导人脐静脉
内皮细胞PPAR-gamma表达的增强,从而可能抑制了OX-LDL信号通路介导的与炎症有关的血管损伤,延缓动脉粥样硬化的进程。 |
英文摘要: |
Objective:To observe the effect of Rosuvastatin on PPAR-gamma in human umbilical vein endothelial cells.Methods:Human umbilical vein endothelial cells were isolated, and the effects of Rosuvastatin on PPAR-gamma expression were evaluated by RT-PCR
andWestern blot.Results:The results demonstrated that concentration dependent and time dependent OX-LDL remarkably decreased the
expression of the expression of PPAR-gamma in human umbilical vein endothelial cells. However rosuvastatin can reverse the impact of
OX-LDL, and the process may be associated with mevalonate.Conclusion:Rosuvastatin can control atherosclerosis process by
stimulating PPAR-gamma expression in human umbilical vein endothelial cells. |
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