| 王茜 刘华 韩冬韧 马耀红 王强.CMV-DNA 与CMV-IgM 对婴幼儿巨细胞感染的诊断价值[J].现代生物医学进展英文版,2015,15(25):4934-4936. |
| CMV-DNA 与CMV-IgM 对婴幼儿巨细胞感染的诊断价值 |
| Diagnostic Value of CMV-DNA and CMV-IgMDetection toCytomegalovirus Infection in Infants |
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| DOI： |
| 中文关键词: CMV-DNA CMV-IgM 巨细胞感染 |
| 英文关键词: CMV-DNA CMV-IgM Cytomegalovirus infection |
| 基金项目:国家自然科学基金青年科学基金项目（30670928） |
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| 中文摘要: |
| 目的：研究尿液CMV-DNA 联合血清CMV-IgM检测对婴儿巨细胞感染的诊断价值。方法：选取2012 年8 月到2014 年8 月
期间我院疑似巨细胞感染的婴幼儿70 例，应用化学发光法检测血清CMV-IgM，采用实时荧光定量PCR法（FQ-PCR）来检测尿液
CMV-DNA，并比较经抗病毒治疗前和治疗后检测结果的变化。结果：单独检测尿CMV-DNA 的阳性率为62.8%（44/70），单独检
测血清CMV-IgM的阳性率为55.7%（39/70），两者比较差异无统计学意义（P＞0.05）；两者联合检测的阳性率为77.1%（54/70），与
两种方法单独检测比较差异具有统计学意义（P＜0.05）；经抗病毒治疗以后两种检测结果均显著降低，与治疗前比较差异具有统
计学意义（P＜0.05）。结论：尿液CMV-DNA联合血清CMV-IgM检测能显著提高婴儿巨细胞感染的阳性率。 |
| 英文摘要: |
| Objective:To study the diagnostic value of CMV-DNA in urine and serum CMV-IgM detection to cytomegalovirus
infection in infants.Methods:70 cases suspected CMV infection in newborns were selected from our hospital during the period from
August 2012 to August 2014, CMV-IgM in serum were detected in chemiluminescence, CMV-DNA in urine were detected in real-time
quantitative PCR (FQ-PCR), before antiretroviral therapy and after treatment changed were compared.Results:Individually tested
positive rate of CMV-DNA in the urine was 62.8% (44/70), separate tested positive rate of CMV-IgM in serum was 55.7%（39/70）, the
difference was no statistically significant (P＞0.05); the positive rate of combined detection was 77.1%(54/70), the difference was
statistically significant compared with individually tested with both methods (P<0.05); two detection results were significantly lower after
treatment by the anti-virus, the difference was statistically significant compared with before treatment (P<0.05).Conclusion:CMV-DNA
in urine and serumCMV-IgMdetection can significantly improve the positive rate of cytomegalovirus infection in infants. |
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