| 闫述钧 韦国千 夏洪远 钟丽华 李学奇.rhBNP治疗射血分数保留急性心力衰竭的临床研究[J].现代生物医学进展英文版,2015,15(25):4899-4901. |
| rhBNP治疗射血分数保留急性心力衰竭的临床研究 |
| rhBNP: A New Strategy for Acute Heart Failurewith Preserved Ejection Fraction |
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| DOI： |
| 中文关键词: 重组人脑利钠肽 急性射血分数保留心力衰竭 治疗 |
| 英文关键词: Recombinant Human Brain Natriuretic Peptide Acute Preserved Ejective Function heart failure Treatment |
| 基金项目:黑龙江省自然科学基金项目（H201428H0212） |
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| 中文摘要: |
| 目的：探讨重组人脑利钠肽(rhBNP)对急性射血分数保留心力衰竭的临床治疗作用。方法：选择2008 年6 月至2014 年6 月
间我院收治的20 例急性射血分数保留心力衰竭患者为研究对象，其中10 例予以硝普钠静脉注射48小时，10 例予以rhBNP 静
脉注射48 小时。48 小时后，评估和比较两组患者心力衰竭的临床改善情况；72 小时后，复查和比较两组患者血浆NT-proBNP 的
下降值。结果：硝普钠组患者呼吸困难缓解积分(1.4± 1.35)明显低于rhBNP 组(3.5± 0.71)，rhBNP 组呼吸困难缓解时间(3.68±
1.69 h)显著短于硝普钠组(21.50± 18.43 h)，血浆NT-proBNP 浓度下降值(864.60± 585.92 pg/ml)明显高于硝普钠组(423.30 ±
284.06 pg/ml)。结论：rhBNP 治疗急性射血分数保留心力衰竭的临床疗效优于硝普钠。 |
| 英文摘要: |
| Objective:To research the clinical efficacy of rhBNP in the treatment of heart failure with preserved ejection fraction
(HF-PEF).Methods:20 cases of patients admitted in hospital due to HF-PEF from june 2008 to june 2014 were enrolled in the research.
10 patients received SodiumNitroprusside threpy for 48h, and the others received rhBNP instead. 48 h later, the clinical improvements of
heart function were assessed and compared between two groups; 72 h later, the plasma concentration of NT-proBNP were rechecked and
compared between two groups.Results:The dyspnea remission integral of sodiumnitroprusside group(1.4± 1.35) was significantly lower
than that of the rhBNP group(3.5± 0.71, P<0.05), the dyspnea remission time of rhBNP group(3.68± 1.69 h) was much shorter than that
of the sodium nitroprusside group(21.50± 18.43 h, P<0.05), the decreased plasma NT-proBNP concentration of rhBNP group(864.60±
585.92 pg/ml) was obviously higher than that of sodium nitroprusside group (423.30± 284.06 pg/ml, P<0.05).Conclusion:The clinical
efficacy of rhBNP was superior to sodiumnitroprusside in the treatment of HF-PEF. |
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