| 严程 朱政鸣 孙晓龙 钟晓 郑小静.伽玛刀联合肝动脉栓塞化疗治疗原发性肝癌的临床疗效观察[J].现代生物医学进展英文版,2015,15(24):4686-4689. |
| 伽玛刀联合肝动脉栓塞化疗治疗原发性肝癌的临床疗效观察 |
| Gamma Knife Combined with Transcatheter Hepatic ArterialChemoembolization for Primary Liver Cancer |
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| DOI： |
| 中文关键词: 伽玛刀 肝动脉栓塞化疗 原发性肝癌 |
| 英文关键词: Gamma Knife Transcatheter hepatic arterial chemoembolization Primary liver cancer |
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| 中文摘要: |
| 目的：研究伽玛刀联合肝动脉栓塞化疗治疗临床疗效，探索治疗原发性肝癌的最优方案。方法：选择2005 年10 月~2013 年
10 月在我院伽玛刀室实施伽玛刀治疗的肝癌病例183 例，随机分为对照组（n=88）和试验组（n=95），对照组患者采取单纯伽马刀
治疗，试验组采用伽马刀联合肝动脉栓塞化疗。治疗后对全部患者进行随访3~24 个月，复查肝功能、甲胎蛋白（AFP）等,追踪有无
不良反应及并发症的出现, 了解其近期与远期疗效。结果：治疗后3 个月复查，对照组和试验组的总体有效率分别为60.5%和
76.84%，两组近期疗效比较，差异具有统计学意义（P<0.05）。两组治疗后肝功能及AFP 改善情况，差异均具有统计学意义（P<0.
05）。两组患者在治疗期间及后均出现不同程度的不良反应，对照组放射诱导的肝病5 例，试验组3 例，经内科对症处理后，患者
情况均好转。试验组在治疗后6、12、18、24 个月的生存率均高于对照组，差异均存在统计学意义（P<0.05）。结论：伽玛刀联合肝动
脉栓塞化疗治疗原发性肝癌的临床疗效优于单纯伽马刀治疗，可进一步研究，进行临床推广。 |
| 英文摘要: |
| Objective:To study the clinical effect of gamma knife combined with transcatheter hepatic arterial chemoembolization,
and to explore the best therapy of primary liver cancer.Methods:A total of 183 cases of liver cancer, who underwent gamma knife
operation in the gamma knife room of Chongqing Fourth People's Hospital from October 2005 to October 2013 were selected and randomly
divided into control group (n=88) and test group (n=95). The control group only underwent the gamma knife operation, while the
test group, gamma knife combined with transcatheter hepatic arterial chemoembolization. After treatment, all the patients were followed
up for 3~24 months. The liver function, alpha fetoprotein (AFP) etc. were reexamined; the adverse reaction, complication and the
short-term and long-term efficacy were analysed.Results:The effective rates in the control group and the testl group were 60.5% and
76.84% respectively, and there was statistical significance in the short-term efficacy, liver function and AFP between the two groups
(P<0.05). There were different degrees of adverse reactions in the two groups during and after treatment. There were 5 cases of radiation-
induced liver cancer in the control group, and 3 cases of radiation-induced liver cancer in the test group, who were all improved after
medical symptomatic treatment. The survival rates 6 th, 12 th, 18 th, and 24 th month after treatment in the test group were significantly
higher than those in the control group, the difference was statistically significant(P<0.05).Conclusion:Gamma knife combined with transcatheter
hepatic arterial chemoembolization has a better clinical efficacy compared with gamma knife in the treatment of patients with
primary liver cancer, which is worthy of further research and clinical promotion. |
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