| The structure and function ofmitochondria is complex and sensitive, with a genome systemindependent on the nucleus.
The shape, quantity and quality of mitochondria are high degree of plasticity, with the different phase, physiological processes and environmental
conditions of the cell. Mitochondria is the main energy supplier of cells and organisms and is a dynamic organ, nearly attending
in all kinds of cells. Normally, mitochondrial mass, morphology and function maintain to be stable, named as mitochondrial homeostasis.
When it comes to be disorder, not only cells but also living body would be influenced, even death. Mitochondrial quantity control
is the focus in mitochondrial homeostasis maintenance, determining the cellular fate. Recently, in the wake of the research of mitochondria,
it is reported that mitochondrial fusion/ fission play a key role in the mitochondrial quality control, referring to mitochondrial morphology,
quantity, DNA and so on. In this review, we will focus on the regulation of mitochondrial fusion and fission on its quality control
and summarize the recent development of mitochondrial fission and fusion, expecting to provide evidence for the following study. |
