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目的：比较急性冠脉综合征患者与健康人血清中γ- 谷氨酰转移酶（γ-GGT）、高敏C- 反应蛋白（Hs-CRP）浓度，探究其水平变化与急性冠脉综合征的相关性。方法：选取我院心血管科收治的急性冠脉综合征患者60 例。根据病情的不同，分为不稳定型心绞痛组30 例和急性心肌梗死组30 例，选取同期进行健康体检的健康人30 例，作为对照组。对三组患者血清中γ-GGT 与 Hs-CRP 水平进行比较。结果：①三组患者血清γ-GGT、Hs-CRP 水平比较：患者血清γ-GGT 水平比较，不稳定型心绞痛组及急性心肌梗死组显著高于对照组，且急性心肌梗死组显著高于不稳定型心绞痛组，差异有统计学意义（P＜0.05）；患者血清Hs-CRP 水平比较，不稳定型心绞痛组及急性心肌梗死组显著高于对照组，且急性心肌梗死组显著高于不稳定型心绞痛组，差异有统计学意义（P＜0.05）；②单支、双支、三支病变组与冠脉64 排螺旋CT 检查阴性组酌-GGT、Hs-CRP水平比较：单支、双支、三支病变组血清中 γ-GGT、Hs-CRP水平明显高于冠脉64 排螺旋CT 检查阴性对照组，差异有统计学意义（P<0.05）；血清中 γ-GGT、Hs-CRP浓度在单支、双支、三支病变组中与病变支数成正向相关。结论：急性冠脉综合征患者血清γ-GGT、Hs-CRP水平显著高于正常值，临床上可根据两者水平变化，进行早期诊断，同时由于血清γ-GGT、Hs-CRP变化较为敏感，可根据观测两者水平，判断冠状动脉病变的严重程度，对急性冠脉综合征患者的早期诊断、病情预测有着重要意义，值得临床广泛应用。

英文摘要:

Objective:To compare the concentration of serum gamma glutamine transferase (gamma GGT), high sensitivity C-reactive protein (Hs-CRP) in acute coronary syndrome (acs) patients and healthy people, and explore the correlation between the change of these two index and acute coronary syndrome (ACS).Methods:60 patients with acute coronary cardiology hospital were admitted. They were divided into unstable angina group (n=30) and acute myocardial infarction group (n=30). Furthermore, 30 cases of healthy people were selected as a control group. The levels of serum γ-GGT and Hs-CRP were compared.Results:① Comparison of serum γ-GGT, Hs-CRP level among three groups: Compared with control group, serum γ-GGT levels in patients with unstable angina and acute myocardial infarction were significantly higher, and acute myocardial infarction group was significantly higher than that stable angina group with statistical significance (P<0.05); compared with control group, serum Hs-CRP levels in the unstable angina and acute myocardial infarction groups were significantly higher, and acute myocardial infarction was significantly higher than the unstable angina group with statistical significance (P<0.05); ② Comparison of γ-GGT and Hs-CRP levels among single, double, and triple coronary artery disease and 64-slice spiral CT negative group: The serum γ-GGT, Hs-CRP levels in single, double, and triple coronary artery lesions were significantly higher than in the 64-slice spiral CT coronary negative control group (P <0.05); and the concentration of serum γ-GGT, Hs-CRP correlated positively with the number of branches of coronary artery lesions.Conclusion:Patients with acute coronary syndrome (acs) serum γ-GGT, and Hs-CRP level were significantly higher than normal, so in clinic, the early diagnosis can be made according to change of their levels, at the same time, serum γ-GGT, Hs- CRP changes were sensitive, so they can be used to judge the severity of coronary artery lesions.

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