| 郭峰 张兴森 徐丽霞 王锋 卢连伟.舒芬太尼与芬太尼对机械通气患者镇痛的效果比较[J].现代生物医学进展英文版,2015,15(23):4548-4550. |
| 舒芬太尼与芬太尼对机械通气患者镇痛的效果比较 |
| Analgesic Effects of Sufentanil and Fentanyl for PatientsUndergoing Mechanical Ventilation |
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| DOI： |
| 中文关键词: 机械通气 芬太尼 舒芬太尼 镇痛 |
| 英文关键词: Mechanical ventilation Sufentanil Fentanyl Analgesia |
| 基金项目: |
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| 中文摘要: |
| 目的：比较舒芬太尼与芬太尼对机械通气（MV）患者镇痛的效果。方法：选择我院2012 年1 月至2014 年1 月收治的87 例
手术室MV 患者，按随机数字表法分为两组，芬太尼组44 例患者应用芬太尼镇痛，舒芬太尼组43 例患者应用舒芬太尼镇痛，比
较两组患者用药前后心率（HR）、自主呼吸频率（RR）、平均动脉血压（MAP）及脉搏氧饱和度（SpO2）基本生命指征变化，同时记录
两组患者芬太尼、舒芬太尼及咪达唑仑用量，MV 时间，持续镇痛时间，手术室滞留时间，比较两组患者用药前后Ramsay评分。结
果：①两组用药后1h（T1）及24 h（T2）HR、RR 及MAP 较用药前(T0)明显下降，SpO2较T0 明显升高，差异有统计学意义（P＜
0.05）；芬太尼组MAP 在T1 及T2 时刻下降程度明显高于舒芬太尼组，差异有统计学意义（P＜0.05）。② 两组患者在T1 时刻
Ramsay评分较T0 时刻明显升高，且舒芬太尼组升高程度明显高于芬太尼组，差异有统计学意义（P＜0.05）。③ 达到较好镇痛效果
水平时，舒芬太尼组患者镇痛药物用量及咪达唑仑用量均明显少于芬太尼组，且舒芬太尼组MV 时间及手术室滞留时间明显短
于芬太尼组，差异有统计学意义（P＜0.05）,两组患者持续镇痛时间比较差异无统计学意义（P＞0.05）。结论：MV 患者使用舒芬太
尼的镇痛镇静效果优于芬太尼，可有效节省咪达唑仑的使用量，缩短MV 及手术室滞留时间，值得临床推广应用。 |
| 英文摘要: |
| Objective:To compare the analgesic effects of sufentanil and fentanyl for patients undergoing mechanical ventilation
(MV).Methods:A total of 87 patients, who were admitted to Dongying District People's Hospital for operation from January 2012 to
January 2014, were selected and randomly divided into two groups: fentanyl group(n=44) and sufentanil group(n=43). Then the changes
of HR, RR, MAP and SpO2 of the two groups before and after treatment were compared; at the same time, fentanyl, sufentanil and
midazolam dosage, MV time, analgesia duration, and retention time in the operation room of the two groups were recorded, and the
Ramsay scores of the two groups before and after treatment were compared.Results:① Compared with before administration, HR, RR
and MAP of the two groups 1 h and 24 h after administration obviously decreased, but SpO2 increased, and the difference was statistically
significant (P<0.05). The decreasing degree of MAP in fentanyl group 1 h and 24 h after administration administraion was obviously
higher than that in sufentanil group, the difference was statistically significant (P<0.05). ② Ramsay scores of the two groups 1 h after
administration was significantly higher than before administration, and the increasing degree in the sufentanil group was significantly
higher than that in fentanyl group, and the difference was statistically significant (P<0.05). ③ When the analgesic effect reached to a
good level, the analgesic dosage and midazolam dosage in sufentanil group were obviously less than those in the fentanyl group, and MV
time and retention time in the operation room in the sufentanil group were significantly shorter than those in fentanyl group, the
difference was statistically significant(P<0.05), but there was no difference in analgesia duration of the two groups(P>0.05).Conclusion:For patients undergoing MV, the administration of sufentanil has a better analgesia and sedative effect than the administration of fentanyl,
which can significantly save the midazolam dosage and shorten the MV time and retention time in the operation room, and is worthy of
clinical application. |
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