| 王瑞菊 田海红 王艳春 华泽权 杨涛.心血管病患者住院治疗期间潜在的药物相互作用研究[J].现代生物医学进展英文版,2015,15(23):4544-4547. |
| 心血管病患者住院治疗期间潜在的药物相互作用研究 |
| A Study on the Potential Drug-drug Interactions in HospitalizedPatients with Cardiovascular Disease |
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| DOI： |
| 中文关键词: 心血管疾病 药物-药物相互作用 互作用程度 Micromedex 数据库 |
| 英文关键词: Cardiovascular disease Drug interaction Interaction severity Micromedex |
| 基金项目:中国博士后基金项目(2013M542567) |
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| 中文摘要: |
| 目的：明确住院治疗的心脏病患者中潜在的药物- 药物相互作用(drug-drug interaction，DDI)，并对DDI相关危险因素进行评
估。方法：选择2013 年5 月至2013 年12 月入院治疗的至少服用2 种药物且入院不少于24 小时的心脏病患者为研究对象，应用
“标准药物相互作用数据库Micromedex -2 (Thomson Reuters) × 2.0”对这些患者可能发生的药物相互作用进行分析。结果：共入
选150 例患者，其中32 例患者被确认出现了至少一种药物组合的DDI，发生率为21.3%；明确了48 个有潜在危险因素的药物相
互作用。阿托伐他汀/ 阿奇霉素(10.4%)、依那普利/ 二甲双胍(10.4%)、依那普利/ 氯化钾(10.4%)、阿托伐他汀/ 克拉霉素(8.3%)、
呋塞米/ 庆大霉素(6.3%)是最常见的存在相互作用的药物组合，阿托伐他汀、依那普利、地高辛、呋塞米、氯吡格雷、华法林等药物
经常参与药物相互作用。大多数药物的相互作用比较温和，但“用药种类增多、住院时间延长、存在合并症”等危险因素与潜在药
物-药物相互作用(potential drug-drug interaction，pDDI)密切相关。结论：住院治疗的心脏病患者潜在DDI发生率较高，用药种类
增多、住院时间延长、存在合并症均为其发生的危险因素。对那些存在明确危险因素的住院治疗的心脏病患者密切监测是十分必
要的，医务人员要尽早发现和预防这些潜在的药物相互作用对人体健康造成的伤害。 |
| 英文摘要: |
| Objective:The study aims to investigate the potential DDI among hospitalized cardiac patients and assess the related
risk factors associated with these interactions.Methods:A total of 150 cardiac patients administered more than 2 types of drugs during
hospital stay for longer than 24 hours were enrolled fromMay 2013 to December 2013. The medications of the patients were analyzed for
possible interactions using the standard drug interaction database-Micromedex-2 (Thomson Reuters)× 2.0.Results:In a total of 150
enrolled patients, at least one interacting drug combination was identified among 32 patients. The incidence of potential DDI was 21.3%.
A total of 48 potentially hazardous drug interactions were identified. Atorvastatin/azithromycin (10.4%), enalapril/metformin (10.4%),
enalapril/potassium chloride (10.4%), atorvastatin/clarithromycin (8.3%) and furosemide/gentamicin (6.3%) were the most common
interacting pairs. Drugs most commonly involved were atorvastatin, enalapril, digoxin, furosemide, clopidogrel and warfarin. Majority of
interactions were of moderate severity (62.5%) and pharmacokinetic (58.3%) in nature. Increased number of medicines, prolonged
hospital stays and comorbid conditions were the risk factors found associated with the potential DDI.Conclusion:The incidence of DDI
in hospitalized cardiac patients was high, increased drug species, prolonged hospitalization and presence of complications were the risk
factors of potential DDI in hospitalized cardiac patients. This study highlighted the need of intense monitoring of patients who had
identified risk factors to help detect and prevent themfromserious health hazards associated with drug interactions. |
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