| 夏卫 王瑞东 倪唯益 王庆 黄吉利.3 种梅毒诊断实验对梅毒患者的临床诊断效果对比[J].现代生物医学进展英文版,2015,15(23):4532-4533. |
| 3 种梅毒诊断实验对梅毒患者的临床诊断效果对比 |
| Comparison of the Effect of Three Diagnosis Experiment Methodsin Patients with Syphilis |
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| DOI： |
| 中文关键词: TPPA USR RPR 梅毒 临床诊断 |
| 英文关键词: TPPA USR RPR Syphilis Clinical diagnosis |
| 基金项目:上海市卫生局科研项目（WJD2009168） |
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| 中文摘要: |
| 目的：对比TPPA(梅毒螺旋体明胶颗粒凝集实验)、RPR(快速血浆反应测定)和USR(不加热血清反应素实验)对不同临床分
期梅毒患者的临床诊断效果。方法：回顾性分析疑似梅毒病患共113 人，其中被确诊为梅毒的99 人，其余14 人正常。对113人均
采用RPR 和USR 初筛实验和TPPA 梅毒确诊实验。评价RPR、USR、TPPA三种诊断的敏感性、特异性、阳性预测值和阴性预测
值。结果：RPR 和USR 对梅毒诊断的敏感性、特异性、阳性预测值和阴性预测值差异无统计学意义(P>0.05)。TPPA各项值均高于
RPR和USR，差异有统计学意义(P 均<0.05)。RPR、USR 对Ⅰ、Ⅱ和Ⅲ期梅毒确诊率无统计学差异(P>0.05)，但TPPA 对Ⅰ、Ⅱ期梅
毒确诊率基本为100%，但是对Ⅲ期梅毒的确诊率降低，且差异有统计学意义(P<0.05)。结论：USR和RPR 对临床梅毒均存在一定
的误诊率，为提高临床疑似病例确诊率，应联合梅毒检测，TPPA 虽为确诊实验，但对Ⅲ期梅毒仍有一定的漏诊率。 |
| 英文摘要: |
| Objective:To compare the diagnosis effect of the TPPA (treponema pallidum gelatin particle agglutination test), RPR
(rapid determination of plasma reaction) and USR (unheated serum reagin test) in patients with different clinical stages of syphilis.Methods:A total of 113 people with suspected of syphilis patients were retrospectively analyzed, of whom 99 were diagnosed with
syphilis and the remaining 14 were normal. All the 113 persons adopted RPR, USR and TPPA diagnosis experiment. RPR, USR and
TPPA diagnostic sensitivity, specificity, positive predictive value and negative predictive value were evaluated.Results:The diagnosis
sensitivity, specificity, positive predictive value and negative predictive value of RPR and USR had no statistical significance (P>0.05).
Each value of TPPA was higher than that of RPR and USR, and the difference was statistically significant (P<0.05). RPR, USR in
SyphilisⅠ, Ⅱ and Ⅲdiagnosis rate had no statistical difference (P>0.05). But the TPPA inSyphilis I and II diagnosis rate was 100%. For
Ⅲ syphilis diagnosis, its rate was reduced, and the difference was statistically significant (P<0.05).Conclusion:USR and RPR have
certain misdiagnosis rate for syphilis at different clinical stages, and in order to increase the rate of clinical suspected diagnosis, they
should be jointed in syphilis detection. TPPA is confirmed experiment, but there is still some missed diagnosis for Syphilis III . |
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