| 崔敏 叶红 孟丽巍 袁振红 张云安.右美托咪定在血管外科介入手术麻醉中的应用[J].现代生物医学进展英文版,2015,15(23):4487-4489. |
| 右美托咪定在血管外科介入手术麻醉中的应用 |
| Application of Dexmedetomidine in Vascular SurgeryInterventional Therapy |
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| DOI： |
| 中文关键词: 右美托咪定 血管外科 介入手术 镇静 |
| 英文关键词: Dexmedetomidine Vascular Surgery Interventional Therapy Sedation |
| 基金项目:黑龙江省教育厅科学技术研究项目（12531315） |
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| 中文摘要: |
| 目的：探讨靶控输注不同浓度右美托咪定对血管外科介入手术的效果。方法：选择周围血管疾病成年患者60 例，随机分为
I、II、III三组，每组20 例。各组右美托咪定靶控输注浓度分别为0.2ug/kg/h，0.3 ug/kg/h 和0.4 ug/kg/h，术中监测并记录各组手术
开始前(T1)，手术开始10 min(T2)，手术开始30 min(T3)，手术开始60 min(T4)四个时间点的平均动脉压（MAP），心率(HR)，血氧
（SpO2），脑电双频指数(BIS)。结果：T2、T3、T4 时平均动脉压Ⅰ组与Ⅱ组比较P<0.05，Ⅰ组与Ⅲ组比较P<0.05。T2 时Ⅲ组与Ⅰ、Ⅱ
组比较P<0.05，T3、T4 时Ⅱ、Ⅲ组与Ⅰ组比较均P<0.05。结论：右美托咪定靶控输注浓度为0.3 ug/kg/h 和0.4 ug/kg/h 时，对血管
外科介入手术能产生良好的镇静作用，并且可保证术中循环的稳定。 |
| 英文摘要: |
| Objective:To study the effects of different target controlled infusion (TCI) rates of dexmedetomidine on interventional
therapy in vascular surgery.Methods:60 patients with peripheral vascular disease were selected and randomly divided into 3 groups (I, II
and III, n=20). The infusion rate of dexmedetomidine for each group was 0.2, 0.3, and 0.4 ug/kg/h, respectively. MAP, HR, SpO2 and
BIS were monitored at four time points: before surgery (T1), 10 min, 30 min and 60 min after surgery (T2-T4).Results:Significant
difference (P<0.05) of MAP between group I and II, group I and III was observed at T2-T4. Meanwhile, significant difference of HR
between group I and III at T2-T4, group I and II at T3/T4, group II and III at T2 was also found.Conclusion:TCI rates of
dexmedetomidine at both 0.3 and 0.4 ug/kg/h can exert good sedative effect on interventional therapy in vascular surgery, and assure
satisfactory intraoperative analgesia at the same time. |
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