| 方晓霞 王云甫 张跃亮 彭晓琴 胡伟 杨新春.依达拉奉联合法舒地尔应用于急性脑梗死患者的治疗效果观察[J].现代生物医学进展英文版,2015,15(22):4355-4357. |
| 依达拉奉联合法舒地尔应用于急性脑梗死患者的治疗效果观察 |
| Effect of Edaravone combined with Fasudil Hydrochloride for the Patientswith Acute Cerebral Infarction |
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| DOI： |
| 中文关键词: 依达拉奉 法舒地尔 急性脑梗死 |
| 英文关键词: Edaravone Fasudil hydrochloride Acute cerebral infarction |
| 基金项目:国家自然科学基金项目（30770875） |
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| 中文摘要: |
| 目的：观察依达拉奉联合法舒地尔应用于急性脑梗死（acute cerebral infarction，ACI）患者的治疗效果及其安全性。方法：选取
我院2011 年1 月-2014 年1 月收治的急性脑梗死患者96 例，随机分为观察组和对照组，每组48例。观察组患者应用盐酸法舒地
尔联合依达拉奉静脉滴注，对照组患者单独应用盐酸法舒地尔静脉滴注射。观察并比较两组患者的治疗效果、神经功能缺损的变
化情况及不良反应的发生情况等。结果：治疗前，两组患者NIHSS、BI评分及NSE 水平比较无明显差异（P<0.05）；治疗后，两组患
者NIHSS、BI评分及NSE水平均较治疗前明显改善，且观察组改善更明显，差异具有统计学意义（P<0.05）；观察组治疗总有效率
高于对照组，差异具有统计学意义（P<0.05）；两组不良反应发生率无明显差异（P>0.05）。结论：依达拉奉联合法舒地尔对急性脑梗
死患者的临床效果显著，不仅可以改善患者的神经功能缺损情况，而且能够改善NSE 水平，值得临床推广应用。 |
| 英文摘要: |
| Objective:To observe the clinical effect of edaravone combine with fasudil hydrochloride on the treatment of the acute
cerebral infarction.Methods:96 cases with acute cerebral infarction who were treated in our hospital from January 2011 to January 2014
were selected and randomly divided into the observation group and the control group, with 48 cases in each group. The patients in the
observation group were received the hydrochloric acid combined with edaravone, while the patients in the control group were only
received the hydrochloric. Then the nerve function defect changes and adverse reactions after the treatment in the two groups were
observed and compared.Results:Before the treatment, there was no statistically significant difference about the NIHSS, BI score and
NSE levels in the two groups (P>0.05); After the treatment, the symptomps improved in the two groups, and the observation group was
better than that of the control group, and the differences were statistically significant (P<0.05); The clinical efficacy rate of the
observation group was higher than that of the control group with statistically significant difference (P<0.05); There was no statistically
significant difference about the incidence of the adverse reactions after the treatment between the two groups (P>0.05).Conclusion:Fasudil hydrochloride combine with edaravone on the treatment of acute cerebral infarction can improve the nerve function and the level
of NSE of patients, which is worthy of clinical promotion and application. |
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