| 张春华 孙海明 乔旨鹰 程辉 张子俊.PCT和CRP在感染性疾病诊断中的临床意义[J].现代生物医学进展英文版,2015,15(22):4348-4350. |
| PCT和CRP在感染性疾病诊断中的临床意义 |
| Application of PCT and CRP in the Diagnosis of Infectious Diseases |
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| DOI： |
| 中文关键词: 降钙素原 急性时相反应蛋白 细菌感染 病毒感染 |
| 英文关键词: PCT CRP Bacteria infection Virus infection |
| 基金项目:卫生部医药卫生科技发展研究中心课题基金（W2011GJ13） |
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| 中文摘要: |
| 目的：探讨PCT、CRP在感染性疾病诊断中的价值，评价两者与感染类型的相关性。方法：回顾性统计分析420 例发热待查的
患者血清PCT，血浆CRP浓度与感染的关系，采用胶体金法检测血清中PCT 的浓度，免疫荧光比色法检测血浆中CRP 浓度，血
培养及血清学的方法检测感染是否存在及感染类型。结果：通过血培养或血清学鉴定出132 例存在细菌感染(细菌组)，病毒感染
103例(病毒组)，细菌病毒混合感染76 例(混合感染组)，109 例阴性(非感染组)。PCT 在细菌组水平最高(20.6± 6.7) 滋g/L，非感染组
水平最低(8.7± 2.3) 滋g/L，四组间差异有统计学意义(F=34.69，P<0.05)。CRP 在混合组中水平最高(18.1± 3.7) mg/L，在非感染组水
平最低(5.8± 1.7) mg/L，四组间差异有统计学意义(F=23.55，P<0.05)。PCT 对细菌感染检测的敏感度为92.7%，特异度为63.2%。
PCT 对病毒感染检测的敏感度为78.7%，特异性为46.0%。细菌感染组、病毒感染组和混合感染组血清CRP 和PCT 均呈正相关
(P=0.00<0.05)。结论：细菌感染的PCT、CRP血清浓度明显高于病毒感染，两者对细菌感染患者的特异性均明显高于病毒感染，细
菌感染PCT 血清浓度较CRP变化敏感。 |
| 英文摘要: |
| Objective:To explore the value of Procalcitonin (PCT) and C-reactive protein (CRP) in the diagnosis of infectious
diseases, and to evaluate their relevance to the type of infection.Methods:A retrospective statistical analysis was performed including
420 cases of patients with fever, and the relationship between serumPCT and CRP levels was analyzed. The concentration of serum PCT
was detected using colloidal gold method and CRP was detected using immunofluorescence colorimetry.Results:Within 420 cases of
patients with fever, 132 cases were diagnosed with bacterial infection through blood cultures or serological detection (bacteria group).
103 cases were diagnosed with virus infection (virus group). 76 cases was detected with bacterial virus infection (mixed group), and 109
cases was detected as negative (negative group). The bacteria group had the highest PCT level (20.6 ± 6.7) ug/L, and the negative group
had the lowest PCT level (8.7± 2.3) ug/L. The PCT level was statistically different between the four groups (F=34.69, P< 0.05). The
CRP level in mixed group was the highest (18.1± 3.7) mg/L, and the lowest in negative group (5.8± 1.7) mg/L. It was also statistically
different between the four groups (F=23.55, P< 0.05). The sensitivity of the PCT for bacterial infections was 92.7%, and specificity was
63.2%. As for detecting virus infection, the sensitivity of PCT was 78.7%, and specificity was 46.0%. CRP and PCT levels in bacterial
infection, virus infection or mixed infection were positively correlated between them (p =0.00 < 0.05).Conclusion:The serum
concentration of PCT and CRP in bacterial infection was obviously higher than that in virus infection. The specificity of PCT and CRP
were both significantly higher in patients with bacterial infection than in those with virus infection. The serum concentrations of PCT in
bacteria infection were more sensitive than the CRP. |
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