| Objective:To investigate the effects of different doses of dexmedetomidine anesthesia for postoperative cognitive
function of lung cancer radical resection patients.Methods:60 cases of patients with lung cancer radical surgery were selected in our hospital,
according to the different doses of dexmedetomidine were divided into A group (High Dose of dexmedetomidine group), group B
(High Dose of dexmedetomidine group) and groupC (without dexmedetomidine). SOD, MDA, recovery time, extubation time and cognitive
function were compared before and 1d, 3 d, 5 d after operation.Results:There was no significant difference between the baseline
data and operation situation of three groups of patients, P > 0.05. The level of SOD was initially decreased, and then increased after the
operation, while the level of MDA was opposite. SOD value in group A on 3rd day was higher than other group, MDA was was significantly
lower in group A on day 1 and 3 than the other two groups, P<0.05. The cognitive function after operation was higher in group A
than the other two groups, and the recovery time and extubation time in group A was superior to the other two groups, P<0.05.Conclusion:Dexmedetomidine anesthesia can reduce oxidative stress injury, cognitive function in patients withlung cancer after radical operation,
shorten the recovery time, drawing tube time. |
