| 马金媛 郑世良 岳萍 李金云 曹娟 侯明.老年2 型糖尿病患者血清中25- 羟维生素D水平
与胰岛beta细胞功能的关系[J].现代生物医学进展英文版,2015,15(21):4091-4093. |
| 老年2 型糖尿病患者血清中25- 羟维生素D水平
与胰岛beta细胞功能的关系 |
| Relationship between 25- Hydroxyvitamin D Levels in Serumand Pancreaticbeta Cell Function in Elderly Patients with Type 2 Diabetes |
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| DOI： |
| 中文关键词: 老年 2型糖尿病 25- 羟维生素D 胰岛beta细胞 |
| 英文关键词: Elderly Type 2 diabetes 25- hydroxyvitamin D Pancreatic beta cell |
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| 中文摘要: |
| 目的：探讨老年2 型糖尿病患者血清中25- 羟维生素D水平与其胰岛素beta细胞功能的相关性，为老年2 型糖尿病的预防和
治疗提供理论基础。方法：选取2013 年6 月至2014 年6 月在我院接受治疗的老年2 型糖尿病患者300 例作为研究对象，另选取
同期在我院参加体检的健康志愿者300 例作为对照组。采用酶联免疫吸附法测定和比较两组研究对象血清中25-羟维生素D 的
含量，采用稳态模型胰岛素抵抗指数(HOMA-IR)、胰岛素敏感指数(IAI)、胰岛beta细胞的功能指数(HBCI)以及空腹胰岛beta细胞的功
能指数(FBCI)评估老年2 型糖尿病患者的胰岛beta细胞功能，并分析老年2 型糖尿病患者血清中25- 羟维生素D 水平与上述参数
的相关性。结果：老年2 型糖尿病患者血清中25-羟维生素D水平为(10.2± 0.9)ng/mL，显著低于正常对照人群(P<0.05)；老年2 型
糖尿病患者血清中25- 羟维生素D 水平与HOMA-IR 呈显著正相关(r=0.438，P=0.019)，与IAI 呈显著负相关(r=-0.392，P=0.023)，
与HBCI和FBCI无明显相关性(P>0.05)。结论：老年2 型糖尿病患者血清中的25- 羟维生素D 水平较低，与其胰岛素beta细胞功能
障碍有关，补充25-羟维生素D 可能有助于老年2 型糖尿病的治疗和预防。 |
| 英文摘要: |
| Objective:To investigate the correlation between the elderly in patients with type 2 diabetes and the insulin beta cells'
function in order to provide a reference for the prevention and treatment of type 2 diabetes.Methods:300 elderly patients with type 2 diabetes
who were treated in our hospital from June 2013 to 2014 were selected as the research group, and another 300 people who had participate
in the examination in our hospital were selected as the control group. The 25- hydroxyvitamin D, the homeostasis model assessment
insulin resistance index (HOMA-IR), the insulin sensitivity index (IAI), the function of islet B cells (HBCI) and the fasting islet B
cell function index (FBCI) were determined by the enzyme linked immunosorbent assay. And the function of islet B cells and insulin resistance
were evaluated, and the correlation between the type 2 diabetes and the vitamin D levels were analyzed.Results:The 25- hydroxyvitamin
D level in the serum of patients with type 2 diabetes was (10.2± 0.9) ng/mL, which was significantly lower than that of the
patients in the control group (P<0.05); The vitamin D was positively correlated with HOMA-IR (r=0.438, P=0.019), and negatively correlated
with IAI (r=-0.392, P=0.023). There was no correlations between 25- hydroxyvitamin D and the HBCI and FBCI (P>0.05). Linear
analysis showed that vitamin D was the influence factors of IAI and HOMA-IR.Conclusion:The 25- hydroxyvitamin D level in the
serumof elderly patients with type 2 diabetes could influence the progress of disease, and the supplyment of 25- hydroxy vitamin D could
be effective for patients with type 2 diabetes. |
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