| 骆静 方丽 袁琦 蔡婷 杨俊伟.线粒体功能障碍在糖尿病肾病进展的作用[J].现代生物医学进展英文版,2015,15(20):3964-3967. |
| 线粒体功能障碍在糖尿病肾病进展的作用 |
| Mitochondrial Dysfunction in the Progression of Diabetic Nephropathy |
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| DOI： |
| 中文关键词: 糖尿病肾病 线粒体功能障碍 线粒体质量控制 线粒体DNA |
| 英文关键词: Diabetic nephropathy Mitochondrial dysfunction Mitochondrial quality control Mitochondrial DNA |
| 基金项目:国家自然科学基金项目（31171093） |
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| 中文摘要: |
| 糖尿病肾病是糖尿病微血管并发症之一，亦是引起终末期肾脏病的主要原因。目前各种临床治疗手段并没有阻止糖尿病肾
病患者肾功能的进行性减退。因此，当务之急是进一步研究糖尿病肾病的发病机制，并从中寻找新的治疗靶点。大量研究结果显
示线粒体功能障碍在糖尿病肾病的发生发展过程中具有重要作用。正常线粒体功能的维持依赖于多方面因素的共同参与，如线
粒体质量控制机制、线粒体DNA等。这篇综述回顾了关于线粒体与糖尿病肾病相关文献，阐述线粒体功能障碍在糖尿病肾病进
展中可能的作用。 |
| 英文摘要: |
| Diabetic nephropathy (DN) is a progressive microvascular complication arising from diabetes and is the leading cause
of end-stage renal disease (ESRD). Current clinical therapies used in individuals with DN do not prevent the inevitable progression to
ESRD. Therefore, better understanding of the pathogenesis of DN and new targets of therapy are urgently required. Ample evidence
indicated that disturbances in mitochondrial dysfunction were central to the pathogenesis of DN．A number of processes sustain healthy
mitochondria in the cell: mitochondrial quality control, mitochondrial DNA and so on. This review took a journey through the past and
summarise the debate about the occurrence of mitochondrial dysfunction and its possible role in the progression of DN. |
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