Article Summary
刘成丽 王丽丽 曲凤占 赵小辉 刘海燕 张士表.右归丸联合小檗碱对多囊卵巢综合征胰岛素抵抗的研究[J].现代生物医学进展英文版,2015,15(20):3943-3945.
右归丸联合小檗碱对多囊卵巢综合征胰岛素抵抗的研究
Influence of Yougui Pill Combined with Berberine on Polycystic OvarySyndrome with Insulin Risistance
  
DOI:
中文关键词: 右归丸  胰岛素抵抗  慢性炎症  小檗碱  多囊卵巢综合征
英文关键词: Yougui Pill  Insulin Resistance  Chronic Inflammation  Berberine  Polycystic Ovary Syndrome
基金项目:沧州市科技计划项目(131302173)
Author NameAffiliation
刘成丽 王丽丽 曲凤占 赵小辉 刘海燕 张士表 河北省沧州中西医结合医院 河北医科大学第二医院河间市计生局技术服务站 
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中文摘要:
      目的:观察右归丸联合小檗碱治疗多囊卵巢综合征(PCOS)的临床疗效。方法:将114 例PCOS伴胰岛素抵抗患者随机分为2 组。对照组57 例给予达英-35+二甲双胍,实验组57 例给予右归丸联合小檗碱治疗。通过比较治疗前后的胰岛素水平(FINS)、胰 岛素抵抗指数(HOMA-IR)、总胆固醇(TC)、甘油三酯(TG)、空腹血糖(FPG)、肿瘤坏死因子(TNF)及白介素-6(IL-6)水平的变化,观察 右归丸联合小檗碱对PCOS 胰岛素抵抗的作用疗效。结果:治疗前后实验组与对照组分别各自比较,HOMA-IR、FINS、TC、TG、 TNF、IL-6 显著下降,差异有统计学意义(P<0.05);两组间治疗前各项指标无统计学意义(P>0.05),治疗后与对照组比较,实验组 TNF、IL-6 水平显著下降(P<0.05)。结论:右归丸联合小檗碱能显著改善患者的血脂及慢性炎症状态,最终改善胰岛素敏感性。
英文摘要:
      Objective:To observe influence of Yougui pill combined with berberine on polycystic ovary syndrome (PCOS) with insulin resistance patients.Methods:114 cases of PCOS were randomly divided into experimental group (Yougui Pill combined with berberine) and control group (metformin and diane-35). The level of TG, TCH FINS, FPG, TNF and IL-6, HOMA-IR were observed and analyzed in order to evaluate the effect of the treatment of two groups.Results:After the treatment, the level of HOMA-IR, FINS, TG, TCH, IL-6, TNF was decreased and had statistics significance (P<0.05). In the pretreatment, there was no significance in the level of FINS, FPG, HOMA-IR, TCH, IL-6, TNF, TC between two groups (P>0.05),but after treatment, the level of IL-6 and TNF in the experimental group was significantly decreased than that in control group (P<0.05).Conclusion:Berberine combined with Yougui pill could decrease the level of lipid and ameliorate chronic inflammation to increase insulin sensitivity.
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