张洁 洪舟 李荣 刘华 孙芳芳.NT-proBNP在慢性充血性心力衰竭中的表达及与NYHA 分级和LVEF的关系[J].现代生物医学进展英文版,2015,15(20):3905-3907. |
NT-proBNP在慢性充血性心力衰竭中的表达及与NYHA 分级和LVEF的关系 |
Expression of NT-proBNP in Chronic Congestive Heart Failure and ItsRelationship with NYHA Grade and LVEF |
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DOI: |
中文关键词: 慢性充血性心力衰竭 NYHA分级 LVEF NT-proBNP |
英文关键词: Chronic congestive heart failure (CHF) New York Heart Association (classification) (NYHA) grad Left ventricular
ejection fraction(LVEF) N-teminalpro-brain natriuretic peptide(NT-proBNP) |
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中文摘要: |
目的:探讨血浆氨基末端脑钠肽前体(NT-proBNP)在慢性充血性心力衰竭(CHF)中的表达及与心功能分级(NYHA)和左室
射血分数(LVEF)的关系。方法:选择我院收治的100 例CHF 患者作为研究组,同时选择同期在我院体检的健康者100 例作为对
照组,分别检测两组NT-proBNP 及LVEF,并对研究组患者NT-proBNP 与NYHA分级和LVEF 进行相关性分析。结果:研究组
NT-proBNP 水平明显高于对照组,LVEF 水平明显低于对照组,差异均有统计学意义(t=9.82,7.63;P<0.01)。研究组血浆
NT-proBNP 水平随着NYHA 分级的升高而显著升高,同时LVEF 水平随NYHA 分级的升高而显著下降(P<0.01)。研究组
NT-proBNP 水平与NYHA 分级呈正相关性(r=0.812,P<0.01),与LVEF 呈明显负相关性(r=-0.623,P<0.01)。结论:血浆
NT-proBNP 水平可早期反映出局部心脏结构改变造成的心功能变化,可与NYHA及LVEF联合检测作为临床诊断CHF的指标。 |
英文摘要: |
Objective:To investigate the expression of N-teminalpro-brain natriuretic peptide (NT-proBNP)in chronic congestive
heart failure (CHF) and its relationship with New York Heart Association (classification) (NYHA) grade and left ventricular ejection
fraction (LVEF).Methods:A total of 100 patients with CHF, who were admitted to Xi'an No.5 Hospital, were chosen as observation
group, and at the same period, 100 healthy persons,who were given health examinations in Xi'an No.5 Hospital, as control group. The
NT-proBNP and LVEF of two groups were detected,and the NT-proBNP, NYHA grade and LVEF in the observation group were
correlatively analyzed.Results:The NT-proBNP level of observation group was markedly higher than that of control group, and the
LVEF level was lower than control group, both differences were statistically significant (t=9.82, 7.63; P<0.01).The level of Plasma
NT-proBNP of observation group significantly increased with increasing NYHA grade,but the level of LVEF significantly decreased with
increasing NYHA grade (P<0.01). The level of NT-proBNP of observation group was positively correlated with NYHA classification
(r=0.812,P<0.01), but negatively correlated with LVEF level(r=-0.623,P<0.01).Conclusion:Plasma NT-proBNP level can early reflect
out the change of heart function caused by local heart structure change,and it combined with NYHA and LVEF can be used as the clinical
test indexes in the diagnosis of CHF. |
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