| 克祯彧 杨桐 付大富 梁媛 覃君慧 王瑞安.H22 腹水型肝癌荷瘤小鼠耐受性的性别差异[J].现代生物医学进展英文版,2015,15(20):3835-3838. |
| H22 腹水型肝癌荷瘤小鼠耐受性的性别差异 |
| Effect of Gender on the Survival of H22 Liver Cancer Bearing Mice |
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| DOI： |
| 中文关键词: 肝癌 H22 细胞 性别 生存期 小鼠 |
| 英文关键词: Liver cancer H22 Gender Survival time Mice |
| 基金项目:国家自然科学基金项目（30971535） |
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| 中文摘要: |
| 目的：观察性别对小鼠H22 腹水型肝癌生长情况的影响，研究不同性别动物对肝癌耐受性的差异。方法：取30 只8 周龄昆
明鼠，雌雄各半，随机分为四组，实验组每组10 只，对照组每组5 只，腹腔接种小鼠H22 肝癌细胞，建立小鼠H22 腹水型肝癌模
型。每天测量小鼠体重并记录生存时间，直至实验组小鼠全部死亡，比较性别因素对小鼠H22 腹水型肝癌的生存期是否存在差
异。结果：小鼠接种瘤细胞后，逐渐产生腹水，体重增加。雌性小鼠的体重增加比雄性小鼠显著，P =0.049。雄性小鼠生存后期体重
出现下降，呈明显恶液质状态。雌性小鼠的体重、腹水增加虽然较雄性动物明显，但生存期却并不少于雄性鼠，反而比雄性小鼠略
长，P =0.1567。结论：性别对小鼠H22 腹水型肝癌的生长有一定的差异，雌性小鼠的耐受性优于雄性小鼠。 |
| 英文摘要: |
| Objective:To observe the effect of gender on the survival of H22 liver cancer bearing mice.Methods:Thirty 8-week
old Kunming mice, half males and half females, were randomly divided into four groups, i.e., male tumor bearing group with 10 animals,
male control group with 5 animals, female tumor bearing group with 10 animals, and female control group with 5 animals. Survival
analysis was conducted by Kaplan-Meier survival function and the log-rank test.Results:After inoculated with H22 cells, the animals
showed sign of ascites in a few days, and body weight grow faster than control animals due to the accumulation of ascites. At the end
stage of life, the male mice demonstrated a significant body weight decrease due to cachexia. The median survival of female mice was
20.5 days, slightly longer than that of male animals (19.5 days). The statistical analysis was not significant though (P=0.1567).Conclusion:Male animals are less tolerant to the liver cancer than female mice. |
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