| 贾斌 栾冠楠 陈宇飞 彭页 罗卓荆 杜俊杰.脊髓型颈椎病的发病机制及治疗的研究进展[J].现代生物医学进展英文版,2015,15(19):3766-3769. |
| 脊髓型颈椎病的发病机制及治疗的研究进展 |
| Advancement on Pathogenesis and Treatment ofCervical Spondylotic Myelopathy |
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| DOI： |
| 中文关键词: 脊髓型颈椎病 发病机制 手术治疗 进展 |
| 英文关键词: Cervical Spondylotic Myelopathy Pathogenesis Surgical treatment Advancement |
| 基金项目:国家自然科学基金项目（81403451）；博士后科学基金项目（2014M562560）；北京市自然科学基金项目（7154242） |
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| 中文摘要: |
| 在中老年人群中脊髓型颈椎病是造成脊髓功能障碍的主要原因，其发病机制复杂，主要有静态和动态因素、缺血、内皮细胞
损伤和血脊髓屏障的破坏、炎症及细胞凋亡等学说，每一种学说并不能够完美的解释脊髓型颈椎病的发病机制，仍需进一步实验
研究探索其机制。对于进行性发展的脊髓型颈椎病多采用手术治疗，手术方式主要有前路、后路及前后路联合手术，如何选择手
术方案仍是临床医生关注的焦点，本文就该病的发病机制及手术治疗的相关进展作一综述。 |
| 英文摘要: |
| Cervical spondylotic myelopathy is the main cause of spinal cord dysfunction in the middle-aged and elderly
populations.There are many theories about the complex pathogenesis of cervical spondylotic myelopathy, such as the static and dynamic
factors, ischemia, endothelial cell loss and compromise of the blood-spinal cord barrier, neuro-inflammation and apoptosis, but none of
themis able to fully interpret the pathogenesis of cervical myelopathy, as a result, further experimental study needs to be carried out so as
to explore its mechanisms. In recent years, the operation methods have become more and more diversified, surgical treatment is widely
used for progressive development cervical spondylotic myelopathy, and there are three main approaches: anterior approach, posterior
approach, combination of anterior and posterior approach. How to choose the surgery project still reminds a focus of the clinicians. This
paper carries out a summary based on the pathogenesis of the disease and the related progress of surgical treatment. |
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