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目的：分析利奈唑胺对肾功能不全G+患者血小板减少的关系。方法：回顾性分析92 例应用利奈唑胺治疗的革兰阳性球菌感染患者的临床资料，根据是否伴有肾功能不全分为肾功能不全组（33 例），正常组（59 例），检测用药前、用药后血小板计数，观察停药后血小板计数恢复正常时间及不良反应发生情况。结果：肾功能不全组治疗后血小板计数显著低于治疗前及正常组（P<0.01)，正常组治疗前、后血小板计数比较无统计学意义（P>0.05)；肾功能不全组血小板减少发生率高于正常组（P<0.05)；停药后正常组血小板恢复正常时间短于肾功能不全组（P<0.01)；肾功能不全组血红蛋白下降率高于正常组（P<0.05)，其余不良反应发生率比较差异无统计学意义（P>0.05)。结论：感染患者肾功能可影响利奈唑胺所致血小板减少发生率，肾功能不全患者在应用利奈唑胺时应定期监测血小板计数。

英文摘要:

Objective:To analyze the relationship of renal dysfunction and linezolid-induced thrombocytopenia.Methods:A retrospective analysis was performed on the clinical data of 92 cases of linezolid-treated patients with Gram-positive bacterial infections. 33 patients with renal dysfunction were designed into the renal dysfunction group, and 59 other patients were assigned as normal group. Detected the platelet before and after treatment, and observe the time for platelet count recovering to normal after treatment and the occurrence of adverse reactions.Results:After treatment, platelet count of renal dysfunction group was significantly lower than before treatment and normal group (P<0.01). There was no statistical difference in platelet count between before and after treatment in the normal group (P>0.05). In renal dysfunction group, the incidence of thrombocytopenia was higher than in the normal group(P<0.05). After treatment, the normal group took shorter time to have the platelet recovered than the renal dysfunction group(P<0.01). Hemoglobin decreased greater in renal dysfunction group than in the normal group (P<0.05). The other incidences of adverse reactions showed no significant differences (P>0.05).Conclusion:The kidney function of infected patients can affect their linezolid-induced thrombocytopenia. Patients with renal dysfunction should have regular monitor on platelet counts when taking linezolid.

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