| 王友于 曾富春 丛伟 薛洋 何彬 张琨.全胸腔镜与后外侧开胸手术对非小细胞肺癌患者炎症因子及免疫功能的影响[J].现代生物医学进展英文版,2015,15(18):3484-3486. |
| 全胸腔镜与后外侧开胸手术对非小细胞肺癌患者炎症因子及免疫功能的影响 |
| Effect of Total Thoracoscopy and Thoracotomy Operation on InflammatoryFactor and Immune Function in Patients with Non Small Cell Lung Cancer |
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| DOI： |
| 中文关键词: 非小细胞肺癌 开胸术 全胸腔镜手术 |
| 英文关键词: Non small cell lung cancer Thoracotomy Thoracoscopic operation |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨全胸腔镜与后外侧开胸手术对非小细胞肺癌患者炎症因子及免疫功能的影响。方法：选择我院80 例非小细胞肺
癌患者，按随机数字表法平均分为两组各40 例，研究组患者使用全胸腔镜手术，对照组采用后外侧开胸手术治疗，比较两组患者
手术时间、术中出血量、输血量及住院天数，同时比较两组患者治疗前后炎症因子及免疫细胞水平变化。结果：研究组患者手术时
间、术中出血量、输血量及住院天数均明显低于对照组，差异有统计学意义（P＜0.05）；两组患者术后细胞炎症因子C- 反应蛋白
(CRP)、淀粉样蛋白A(SAA)、白细胞介素-6(IL-6)及可溶性白介素2 受体(IL-2R)均较术前明显升高，且对照组患者各因子水平升
高程度明显高于研究组，差异有统计学意义（P＜0.05）；两组患者术后T 淋巴细胞中CD4＋、CD8＋及CD4+/CD8+均较术前明显下
降，且对照组患者下降程度明显高于研究组，比较差异具有统计学意义（P＜0.05）。结论：全胸腔镜手术治疗早期非小细胞肺癌疗
效显著，且利于保护机体免疫功能，值得临床推广应用。 |
| 英文摘要: |
| Objective:To investigate the effect of total thoracoscopy and thoracotomy operation on inflammatory factor and
immune function in patients with non small cell lung cancer.Methods:80 patients with non small cell lung cancer in our hospital were
selected and randomly divided into two groups, 40 in each group. The study group was treated with total thoracoscopic operation, while
the control group, used posterolateral thoracotomy operation. The operation time, intraoperative bleeding, transfusion, and hospital stay of
the patients in the two groups, as well as inflammatory factors and immune cell levels before and after treatment were compared.Results:The operation time, intraoperative bleeding, transfusion and hospital stay of the study group were significantly lower than those of the
control group,with significant difference (P<0.05); Inflammatory cytokines CRP, SAA, IL-6 and IL-2R of the two groups after treatment
obviously increased compared to before operation, and each factor level in the control group elevated significantly higher than that in the
study group, with significant difference (P<0.05); CD4 +, CD8 + and CD4+/CD8+ in T lymphocytes of the two groups after treatment
decreased compared to before operation, and that in the control group obviously decreased higher than that of the study group, with
statistical significance (P<0.05).Conclusion:Total thoracoscopic operation has a significant effect in treatment of early stage non small
cell lung cancer, can protect the body's immune function, and is worthy of clinical application. |
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