| 方阅 张渊 方敏 刘皋林 白利民.中药联合化疗对ALL患者CD4、CD25 细胞调节及sE-cad 的影响[J].现代生物医学进展英文版,2015,15(18):3466-3469. |
| 中药联合化疗对ALL患者CD4、CD25 细胞调节及sE-cad 的影响 |
| Effect of Traditional Chinese Medicine Combined with Chemotherapy forPatients with ALL CD4, the Regulation of CD25 Cell and sE-cad |
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| DOI： |
| 中文关键词: 中药 血清sE-cad CD4+ CD25+ |
| 英文关键词: Chinese traditional medicine serumsE-cad CD4+ CD25+ |
| 基金项目:国家自然科学基金项目（H0136） |
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| 中文摘要: |
| 目的：研究中药联合化疗方案对急性淋巴细胞白血病（Acute lymphocytic leukemia, ALL）患者CD4+、CD25+细胞调节的影
响、血清sE-cad 的影响以及临床意义。方法：选取我院血液科收治的急性淋巴细胞白血病患者60 例，随机分为两组，其中对照组
30 例给予常规化疗方案治疗，中药组30例在常规化疗方案的基础上加用中药辅助治疗。对比治疗前后患者血常规、CD4+、CD25+
细胞及血清sE-cad 的改变。结果：①治疗后两组患者CD4+、CD25+T细胞较治疗前均显著下降，差异有统计学意义（P＜0.05），与对
照组相比，中药组CD4+、CD25+T 细胞下降明显，差异有统计学意义（P＜0.05）；②治疗后两组患者血清sE-cad 均改善，且中药组
（55.58± 10.47）较对照组（67.27± 11.32）明显下降，差异有统计学意义（P＜0.05）；③两组有效率比较重，中药组总有效率（86.67
%）明显优于对照组（66.67 %），差异有统计学意义（P＜0.05）。结论：中药联合化疗治疗急性淋巴细胞白血病CD4+、CD25+T 细胞调
节及血清sE-cad 的改变明显，对临床具有指导意义。 |
| 英文摘要: |
| Objective:To study traditional Chinese medicine combined with chemotherapy for acute lymphoblastic leukemia
(Acute lymphocytic leukemia, ALL) in patients with CD4+, CD25+ cell regulation effect, serum sE-cad and the effect of clinical
significance.Methods:60 patients with acute lymphoblastic leukemia in our hospital chosen from the Department of Hematology were
randomly divided into two groups; 30 patients in control group received conventional chemotherapy treatment, 30 cases of the Chinese
medicine group were treated by traditional Chinese medicine auxiliary based on conventional chemotherapy. Change the blood routine
test, CD4+, CD25+ cells and serum sE-cad before and after treatment were compared.Results:After treatment, patients in the two groups
with CD4+, CD25+T cells were significantly lower than that before treatment, and the difference was statistically significant (P < 0.05);
compared with the control group, CD4+, CD25+T cells, the Chinese medicine group decreased significantly, and the difference was
statistically significant (P < 0.05); after the treatment , serum sE-cad of the two groups of patients were both improved, and decreased
significantly in the traditional Chinese medicine group (55.58 + 10.47) than in the control group (67.27 + 11.32), and the difference was
statistically significant (P < 0.05); the two group's efficiency is relatively heavy, total effective rate of the traditional Chinese medicine
group(86.67%) was significantly better than that of the control group (66.67%), and the difference was statistically significant (P < 0.05).Conclusion:Traditional Chinese medicine combined with chemotherapy in the treatment of acute lymphoblastic leukemia CD4+ and
CD25+T cells modulate and serumsE-cad change significantly, has the guidance significance for clinical. |
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