| 吴晓宁 陈克研 张铁铮 孙莹杰 周锦 王洪乾.七氟醚与体外循环脑损伤保护作用研究进展[J].现代生物医学进展英文版,2015,15(17):3374-3378. |
| 七氟醚与体外循环脑损伤保护作用研究进展 |
| Advanced Study of Sevoflurane and its Neuroprotectionduring Cardiopulmonary Bypass |
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| DOI： |
| 中文关键词: 七氟醚 体外循环 脑保护 预处理 后处理 |
| 英文关键词: Sevoflurane Cardiopulmonary bypass Neuroprotection Preconditioning Postconditioning |
| 基金项目:辽宁省自然科学基金项目（20102244） |
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| 中文摘要: |
| 心血管外科手术中，体外循环术后的神经系统并发症可延长住院时间、增加死亡率及其他并发症，已成为阻碍心外科手术
发展的重要因素。七氟醚作为一种具有神经保护作用的吸入性麻醉药正在逐渐引起人们的重视，本文结合国内外相关的七氟醚
与脑缺血再灌注损伤的基础与临床研究，总结目前研究现状以及存在问题，从以下几个方面对七氟醚在体外循环脑损伤中的脑
保护作用进行阐述：七氟醚增加脑血流、降低脑氧代谢率；线粒体ATP敏感性钾通道介导七氟醚神经保护的作用；TLR 与心血管
手术脑保护研究；七氟醚预处理后处理与心血管手术；七氟醚在心血管手术中脑保护作用。基于目前研究，为了确保七氟醚在心
血管手术麻醉中更有效、安全地应用，有关七氟醚体外循环脑损伤保护作用的复杂机制及七氟醚最佳使用剂量－保护效应之间
的关系仍需要进一步的探索，以期为临床提供理论基础。 |
| 英文摘要: |
| Because the postoperative neurological complications of CPB can extend the length of hospital stay, increase the
mortality rates and cause other complications, it has been one the most important factor to hinder the development of cardiac surgery.
Sevoflurane, as a kind of neuroprotective inhalation anesthetics, is gradually arousing people's attention. This article combined the
relevant basic and clinical research in domestic and foreign to expound the neuroprotection of sevoflurane against cerebral ischemia
injury fromthe following aspects: Sevoflurane can increase the cerebral blood flow and decrease the rate of cerebral oxygen metabolism;
Mitochondrial ATP channel medicates the neuroprotection of Sevoflurane; The research of TLR and neuroprotection during cardiac
surgery; Preconditioning and postconditioning during cardiac surgery; The neuroprotection of Sevoflurane during cardiac surgery. To
ensure the sevoflurane can applied in cardiac anesthesia more effective and safer, the complex neuroprotective mechanisms and optimal
dose-protective effect of sevoflurane during cardiopulmonary bypass need more explore. |
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