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目的：探究甲状旁腺激素（PTH）及血清钙（Ca）水平与脓毒症患者病情严重程度和预后的关系。方法：选取2010 年9 月至 2014 年2 月我收治的80 例脓毒症患者，根据存活情况分为存活组（38 例）和死亡组（42 例），根据血Ca 水平分为正常血钙组（32 例）和低血钙组（48 例）。检测患者PTH、Ca 水平，采用急性生理和慢性健康评分(APACHE II)评价患者病情严重程度，分析 APACHEII评分与PTH、Ca 水平的相关性，以及Ca 水平与预后的关系。结果：生存组PTH水平及APACHE II 评分均低于死亡组，血Ca 水平高于死亡组，差异均统计学意义(P<0.05)；APACHEII评分与血Ca 呈负相关(r=-0.581，P <0.05），与PTH 水平呈明显正相关(r=0.423，P<0.05)；正常血钙组治疗后死亡率为25.00%（8/32），低于低血钙组的66.67%（32/48），差异有统计学意义(x2=13. 333，P<0.05)。结论：PTH及Ca 水平与脓毒血症患者病情严重程度有显著关系，低血Ca 提示患者预后差。

英文摘要:

Objective:To explore the relationship between parathyroid hormone (PTH), serumcalcium (Ca) and disease severity, prognosis of sepsis patients.Methods:80 cases of sepsis patients were treated in our hospital between September 2010 and February 2010, which were divided into survival group (38 cases) and death group (42 cases) according to the survival situation, and were divided into normal calcium group (32 cases) and low calcium group (48 cases) according to the Ca level. The PTH and serum Ca level were detected, the disease severity was evaluated using the acute physiology and chronic health score (APACHEII). Analyzed the correlation between APACHE II score and PTH, serum Ca level, and the relationship between Ca level and prognosis.Results:The PTH level and APACHE II score of the survival group was lower than that in death the group, the serum Ca level was higher than that of death group, the difference was statistically significant (P<0.05); APACHEII score was negatively correlated with serum Ca (r=-0.581, P<0.05), while positively correlated with the PTH level (r=0.423, P<0.05); After treatment, the mortality rate of normal calcium group was 25%(8/32), lower than 66.67%(32/48) in the low calciumgroup, the difference was statistically significant (x2=13.333, P<0.05).Conclusion:There is a significant relationship between serum PTH and Ca level and disease severity of sepsis patients, and Low serum Ca indicates a poor prognosis.

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