| 张佳 黄昌林 常祺 郭延岭 翟艺宗.脉冲电流经皮刺激肝区对运动性疲劳大鼠5-HT 及其代谢的影响[J].现代生物医学进展英文版,2015,15(17):3259-3263. |
| 脉冲电流经皮刺激肝区对运动性疲劳大鼠5-HT 及其代谢的影响 |
| Influence of Percutaneous Impulsive Current Stimulationof Hepatic Region on the Concentration of 5-HT and ItsMetabolismin Exercise-induced Fatigue Rats |
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| DOI： |
| 中文关键词: 脉冲电流 中枢疲劳 纹状体 5-羟色胺 |
| 英文关键词: Impulsive current Central nervous systemfatigue Striatum 5-hydroxytryptamine |
| 基金项目:全军卫生和疾病防控应用性研究课题计划(13BJYZ18) |
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| 中文摘要: |
| 目的：研究脉冲电流经皮刺激肝区对运动性疲劳大鼠大脑纹状体5-羟色胺（5-HT）及其代谢的影响。方法：8 周龄Wistar雄
性大鼠80只随机分为安静对照组（CG组）、疲劳训练组（FG 组）、运动后刺激组（SAF组）、运动前刺激组（SBF 组），除CG组外各
组均进行游泳训练，建立运动疲劳模型，于第1、3、5 周训练的最后1d，断头处死, 取外周血测游离色氨酸(F-Trp)、支链氨基酸
（BCAA）、F-Trp/ BCAA 含量,取纹状体测F-Trp、5-HT、5-羟吲哚乙酸(5-HIAA) 含量。结果：与CG组相比, 各组大鼠血清BCAA
含量呈下降趋势, 其余各指标均呈升高趋势；与FG 组相比，SAF 组、SBF组第3 周末纹状体5-HT 明显下降（P＜0.01）；与SBF组
相比, SAF 组第5 周末纹状体5-HT 明显下降（P＜0.05）。结论：经皮脉冲电流刺激具有降低疲劳大鼠5-HT 及代谢产物的含量，有
助于疲劳的消除，对长时间运动时中枢机能的改善具有积极作用。 |
| 英文摘要: |
| Objective:To investigate the effects of percutaneous impulsive current stimulation of hepatic region on the concentration
of 5-hydroxytryptamine (5-HT) and its metabolism in striatum of fatigued rats.Methods:80 Eight-week-year old Wistar male rats
were randomly divided into four groups: control group( CG), fatigue group( FG), stimulation after fatigue group( SAF) and stimulation
before fatigue group(SBF). All of the groups were given the swimming training to establish exercise-induced fatigue model except for the
CG group. Rats were killed immediately, The level of free-tryptophan(F-Trp), branched chain amino aci(BCAA) and the ratios of F-Trp/
BCAA were Measured in blood serum of rats , the concentration of F-Trp, 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) were tested in
Striatumof Rats.Results:Compared with CG group, the concentrations of BCAA in blood serumof rats in every group tended to decline,
other indexes were all increased. Compared with FG group, the concentrations of 5-HT in rats’striatumin SAF group and SBF group declined
significantly（P＜0.01) at the weekend of 3rd week. Compared with SBF group, the concentrations of 5-HT in rats’striatumin SAF
group declined significantly（P＜0.01) at the weekend of 5th week.Conclusion:Percutaneous impulsive current stimulation of hepatic
region can effectively lessen the concentration of 5-HT and its metabolismin fatigued rats, which could suspend the occurrence of fatigue
and help to eliminate the fatigue，improve rat central nerves performance in long time exhausted exercise． |
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