| In recent years, many studies have shown that Ki67 expression is closely related to the development of different kinds
of tumors, such as breast cancer, ovarian cancer, lymphoma, etc. Clinically, Ki67 index is usually detected by immunohistochemical
(IHC) to reflect the proliferative activity of normal and diseased tissue, which may help identify the benign and malignant disease. As a
reference value, it guides a lot in the early diagnosis, treatment and evaluation of curative effect. But in clinical and basic research, there
is no fixed threshold of Ki67 that can help determine the malignance; moreover, a precise Ki67 value is not enough to quantify the
malignance of tumor. In some cases, the dynamic tracking for Ki67 is essential for optimizing treatment and prognosis. In this article, the
correlations of Ki67 index with malignant grade, therapeutic effect and prognostic prediction of different kinds of tumors are reviewed. |
