| 马敏 张明月 何沙沙 文雯 王国年.大麻素受体2 在吗啡耐受中的作用[J].现代生物医学进展英文版,2015,15(16):3186-3188. |
| 大麻素受体2 在吗啡耐受中的作用 |
| The Role of Cannabinoid Receptor 2 in Morphine Tolerance |
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| DOI： |
| 中文关键词: 吗啡耐受 大麻素受体2 胶质细胞 |
| 英文关键词: Morphine tolerance Cannabinoid receptor 2 Glial cells |
| 基金项目: |
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| 中文摘要: |
| 吗啡在疼痛治疗中广泛应用，但其长期使用可以导致耐受，这大大影响了其临床应用价值，吗啡耐受是临床亟待解决的问
题。研究发现大麻素受体2 ( cannabinoid receptor 2, CB2 受体)参与吗啡耐受的发生与发展。CB2 受体选择性激活剂与吗啡联合使
用，可以减弱吗啡诱导产生的痛觉过敏和异常疼痛，抑制吗啡耐受的发生与发展。激活CB2 受体抑制吗啡耐受的机制尚未明确，
本文将就CB2 受体在吗啡耐受中作用的研究现状作一综述。 |
| 英文摘要: |
| Morphine is widely used in the treatment of pain, but its long-termuse can lead to tolerance, which greatly affected its
clinical value. Morphine tolerance is a clinical problems to be solved. Studies have found cannabinoid receptors 2 involved in the
occurrence and development of morphine tolerance. Selective CB2 receptor activator combined with morphine, can attenuate morphine
induced hyperalgesia and allodynia, inhibition of morphine tolerance. The mechanisms of that CB2 receptor activation inhibits morphine
tolerance are not clear yet, which provides an overview of the role of the CB2 receptor in morphine tolerance. |
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