| 罗淑红 石慧萍 张青冬 彭浩 史全海 张淑兰.PVB 与PF方案对局部晚期宫颈癌PTEN、VEGF和CD105 表达的影响[J].现代生物医学进展英文版,2015,15(16):3100-3102. |
| PVB 与PF方案对局部晚期宫颈癌PTEN、VEGF和CD105 表达的影响 |
| Comparison of PVB and PF on the Expressions of PTEN, VEGF and CD105in Advanced Cervical Carcinoma |
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| DOI： |
| 中文关键词: 新化疗方案 晚期宫颈癌 PTEN VEGF CD105 |
| 英文关键词: New chemotherapy Advanced cervical cancer PTEN VEGF CD105 |
| 基金项目:国家自然科学基金项目（30672220） |
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| 中文摘要: |
| 目的：比较PVB与PF方案对局部晚期宫颈癌患者PTEN、VEGF 和CD105 表达的影响。方法：选取我院妇科收治的局部晚
期宫颈癌患者150 例，随机分为两组，其中PVB 组75 例予顺铂、长春新碱、博来霉素化疗；PF 组75 例予博来霉素、顺铂配合5-
氟尿嘧啶治疗。观察并对比治疗前后患者临床疗效及患者癌组织PTEN、VEGF 表达阳性率、CD105抗体标记的肿瘤MVD值等
指标。结果：①治疗后两组PTEN、VEGF表达阳性率均有所改善，与PVB 组（76.3 %）比较，PF组PTEN 表达阳性率（88.3 %）明显
升高，差异有统计学意义（P＜0.05）；与PVB 组（15.3 %）比较，PF组VEGF表达阳性率（6.7 %）明显降低，差异有统计学意义（P＜
0.05）；②治疗后两组MVD 值均有所改善，与PVB 组（38.93± 9.89）比较，PF 组MVD 值（35.61± 10.33）明显降低，差异有统计学
意义（P＜0.05）；③治疗后，与PVB组（76.67 %）比较，PF 组的有效率（86.67 %）明显较高，差异有统计学意义（P＜0.05）。结论：与
PVB 方案相比，PF方案能够使局部晚期宫颈癌患者PTEN 表达水平升高，降低VEGF和CD105 表达水平，临床疗效更确切。 |
| 英文摘要: |
| Objective:To compare the effect of PVB and PF regimens on the expression of PTEN, VEGF and CD105 in locally
advanced cervical cancer patients.Methods:150 patients with locally advanced cervical cancer in our hospital were selected for
gynecological patients, then they were randomly divided into two groups; 75 cases in group PVB, treated with cisplatin, vincristine,
bleomycin chemotherapy; 75 cases in group PF, treated with bleomycin, cisplatin combined with 5- fluorouracil treatment. The curative
effects and the positive expression rate of PTEN, VEGF and CD105 antibody labeled tumor MVD value index were compared before and
after treatment between the two groups.Results:①After treatment, the positive expression rate of PTEN and VEGF were improved in the
two groups, and for the PF group, PTEN expression was obviously increased and VEGF expression was significantly decreased with
statistical significance compared with that in the PVB group (P<0.05); ② after the treatment, the value of MVD of both groups was
improved, and MVD was decreased more significantly in the PF group than in the PVB group (P<0.05); ③ in comparison of efficiency
rate, it was significantly higher in the PF group than in the PVB group, and the difference was statistically significant (P<0.05).Conclusion:Compared with PVB scheme, PF scheme can increase PTEN expression level of the patients with locally advanced cervical
cancer, as well as decrease VEGF and CD105 expression level, therefore, PF scheme has a more exact clinical curative effect. |
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