| 曹雄彬 南毛球 匡良洪 刘雅芳 孙元平 颜莉蓉.丘脑底核脑深部电刺激治疗帕金森病的临床分析[J].现代生物医学进展英文版,2015,15(16):3092-3095. |
| 丘脑底核脑深部电刺激治疗帕金森病的临床分析 |
| Clinical Analysis of Targeting Subthalamic Nucleus for Deep BrainStimulation for Parkinson's Disease |
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| DOI： |
| 中文关键词: 脑深部电刺激手术 丘脑底核 帕金森病 临床表现 |
| 英文关键词: Deep brain stimulation surgery Subthalamic nucleus Parkinson's disease Clinical manifestations |
| 基金项目: |
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| 中文摘要: |
| 目的：通过丘脑底核脑深部电刺激术治疗帕金森病，观察其肌肉僵直、静止性震颤、运动迟缓等症状的改善情况。方法：选取
以丘脑底核为刺激靶点收治的帕金森病患者8 例，对比手术前后患者肌强直、静止性震颤、运动迟缓等症状的改善情况，并进行
UPDRS评分。结果：接受丘脑底核脑深部电刺激术治疗帕金森病6个月后，患者肌肉僵直、静止性震颤、运动迟缓等临床主症的改
善上效果良好；与手术前相比，患者术后UPDRS 评分均有所降低，差异具有统计学意义（P＜0.05）；患者术后美多巴服用量显著减
少，差异具有统计学意义（P＜0.05）；患者术后没有产生永久性的并发症以及较明显的临床症状；但对大量油脂性渗出及典型面具
性面容的治疗上未见明显疗效。结论：丘脑底核脑深部电刺激术治疗帕金森氏病，可以使帕金森病主要临床症状肌肉僵直、静止
震颤及运动迟缓得到明显改善，显著减少美多巴服药量，具有安全可靠的疗效，对临床具有指导意义，值得临床推广应用。 |
| 英文摘要: |
| Objective:To observe the curative effects of targeting subthalamic nucleus for deep brain stimulation on the main
clinical symptoms of muscles in patients with Parkinson's disease including muscle rigidity, resting tremor and bradykinesia.Methods:8
cases of Parkinson's disease patients were selected and treated by stimulating subthalamic nucleus as the target. The improvement of
symptoms, such as muscle rigidity, resting tremor, and bradykinesia were detected before and after surgery, and UPDRS scores were
compared.Results:Six months after accepting the deep brain stimulation of subthalamic nucleus, the main clinical symptoms of muscles
was obviously improved for the patients with Parkinson's disease including the muscle rigidity, resting tremor, bradykinesia, and so on.
Compared with before surgery, postoperative UPDRS ratings reduced (P ＜0.05), and the postoperative madopar dose was also
significantly decreased（P＜0.05). No obvious permanent postoperative complications were detected; but the deep brain stimulation of
subthalamic nucleus had no significant effect on the treatment of a large number of oil exudation and typical face of masks.Conclusion:The deep brain stimulation of subthalamic nucleus can significantly improve the main clinical symptoms of Parkinson's disease, including
muscle rigidity, tremor and bradykinesia, and also can obviously reduce the dose of medication madopar, indicating safe and reliable
curative effects. |
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