| 王磊 李军农 尤菲 张亚敏 袁铭 郭文怡.非ST 段抬高急性冠脉综合征患者心衰程度与血浆IL-15 水平的相关性研究[J].现代生物医学进展英文版,2015,15(16):3077-3081. |
| 非ST 段抬高急性冠脉综合征患者心衰程度与血浆IL-15 水平的相关性研究 |
| Correlative Research on the Degree of Heart Failure in Patients withNon-ST-segment Elevation Acute Coronary Syndrome with IL-15 in Plasma |
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| DOI： |
| 中文关键词: 非ST 段抬高急性冠脉综合症 心衰 白介素15 脑尿钠肽 EF值 |
| 英文关键词: NSTE-ACS Heart failure IL-15 BNP EF |
| 基金项目:国家自然科学基金青年科学基金项目（81200189） |
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| 中文摘要: |
| 目的：分析非ST 段抬高急性冠脉综合征(NSTE-ACS)患者心衰程度与血浆IL-15 水平的相关性及其临床意义。方法：选择
NSTE-ACS 不伴心衰及NSTE-ACS 伴心衰住院患者154 例，对照组为冠脉造影排除冠心病诊断者20 例。冠脉造影前，采用
ELISA法测定和比较各组的血浆IL-15 水平，通过pearson 相关检验分析血浆IL-15 水平与NSTE-ACS 患者心衰程度的相关性；
散点图及拟合曲线观察血浆IL-15 水平与NSTE-ACS 患者心衰程度的关系；多元线性回归对差异变量进行调整，进一步明确血浆
IL-15 水平与NSTE-ACS患者心衰程度的关系。结果：NSTE-ACS不伴心衰组和NSTE-ACS 伴心衰组患者的血清IL-15 水平均显
著高于正常对照组(P<0.01)；且NSTE-ACS伴心衰组的患者血清IL-15 水平较NSTE-ACS 不伴心衰组患者显著升高，差异具有显
著统计学意义(P<0.01)。Pearson 检验结果显示血浆IL-15 水平与EF 值呈负相关(r=-0.775)，与血清BNP水平呈正相关(r=0.474)；
散点图显示IL-15能与EF值线性拟合，呈负相关；散点图显示IL-15 与血清BNP 水平线性拟合，呈正相关；多元线性回归调整差
异变量，明确IL-15 与EF值(beta= -0.295)呈显著相关。结论：NSTE-ACS 患者的血浆IL-15 水平与其心衰严重程度呈正相关。 |
| 英文摘要: |
| Objective:To analyze the correlation of IL-15 and degree of heart failure in non st-elevation acute coronary syndromes
(NSTE-ACS) patients and its clinical significance.Methods:Before coronary anfiography, the level of serumIL-15 level was measured in
control (20 patients) and NSTE-ACS patients with or without heart failure (154 patients) by sandwich ELSIA, meanwhile, heart failure
indicator(serum BNP level and EF) were measured; The relationship between IL-15 and heart failure indicator(serum BNP level and EF)
was analyzed by pearson correlation coefficient test and linear fitting; Further verifying the serum IL-15 level with heart failure through
adjusting variables by Multiple linear regression.Results:The levels of serum IL-15 in NSTE-ACS patients with or without heart failure
were significantly higher than that of the control group (P<0.01). Also, the level of serum IL-15 in NSTE-ACS patients with heart failure
was significantly higher than that of NSTE-ACS patients without heart failure(P<0.01). Pearson correlation coefficient test(r=-0.775) and
linear fitting showed a negative relation between IL-15 and EF; Pearson correlation coefficient test (r=0.474) and linear fitting showed a
positive relation between IL-15 and BNP; Multiple linear regression adjust variables, where there was difference between the groups,
also demonstrated that the levels of IL-15 had negative correlation with EF (beta=-0.295).Conclusion:There was a close correlation
between serumIL-15 level and stage of heart failure in NSTE-ACS patients. |
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