| 李晶晶 周超飞 陈逸伦 耿晓雯 高洁 任艺虹.冠心病患者静息心率与血小板活性相关研究[J].现代生物医学进展英文版,2015,15(16):3061-3064. |
| 冠心病患者静息心率与血小板活性相关研究 |
| Related Research of Resting Heart Rate and Platelet Activity in Patients withCoronary Heart Disease |
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| DOI： |
| 中文关键词: 冠心病 静息心率 血小板活性 |
| 英文关键词: Coronary heart disease Resting heart rate Platelet activity |
| 基金项目:国家自然科学基金项目(81270309) |
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| 中文摘要: |
| 目的：探讨冠心病患者静息心率与血小板活性的相关研究。方法：选择2013 年1 月至2014 年9 月于我院住院患者474 例，
按静息心率快慢分为三组，心率<70 bmp 为第一组(Q1)150 例，心率位于70~85 bmp 为第二组(Q2)265 例，心率>85 bmp 为第三组
(Q3)59 例，三组患者均于病情稳定时行血栓弹力图(TEG)中MA 值检测，同时随访3 个月，观察和比较三组患者MA 值变化及预
后。结果：三组患者MA 值分别为61.16± 7.29 mm、62.02± 7.46 mm、65.32± 6.56 mm，第三组患者MA 值与第一组或第二组患者
MA 值比较差异均存在统计学意义(P<0.05)，通过血栓弹力图检测三组经花生四烯酸(AA)途径的血小板抑制率和经二磷酸腺苷
(ADP)途径的血小板抑制率发现，静息心率高低与抗血小板药物作用疗效无相关关系(P>0.05)。随访3 个月，三组患者心绞痛、再
住院、脑血管病及死亡的总发生率分别为28 %、28.68 %、40.67 %。结论：冠心病患者静息心率越快，MA 值越大即血小板活性越
高，静息心率的高低与抗血小板药物作用疗效无关。 |
| 英文摘要: |
| Objective:To analyze the relationship between resting heart rate and platelet activity in patients with coronary heart
disease.Methods:474 cases of patients with coronary heart disease admitted in our hospital from January 2013 to September 2014 were
selected for this study. There were 150 cases of patients' resting heart rate lower than 70 bmp (Q1 group), and 265 cases of patients'
resting heart rate between 70 bmp and 85 bmp (Q2 group), and 59 higher than 85bmp (Q2 group). All the patients were detected MA
value in thrombelastography (TEG), and followed up for 3 months. The MA value and prognosis were compared among three groups.Results:The MA value of three groups were 61.16± 7.29 mm, 62.02± 7.46 mm, 65.32± 6.56 mm. There were significant differences
between Q1 and Q3, and between Q2 and Q3 (P<0.05). Through ADP and AA pathway, the effect of antiplatelet agents were observed
and compared among the three groups, the results showed that resting heart rate was not related with the effect of antiplatelet agents.
After 3 months, follow-up, the total incidence of adverse events including angina, rehospitalization, cerebrovascular disease and death
were 28 %, 28.68 %, and 40.67 % in the three groups, respectively.Conclusion:The patients of coronary heart disease with the faster
resting heart rate had the greater MA value, which meant the higher platelet activity, and the level of resting heart rate was not related
with the effect of antiplatelet agents. |
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