| 刘辉 吕丽琼 莫小勤 成名 杨杰.MMP-2、MMP-7、MMP-9、TIMP-1 及TIMP-2在乳腺癌组织中的表达及意义[J].现代生物医学进展英文版,2015,15(16):3046-3048. |
| MMP-2、MMP-7、MMP-9、TIMP-1 及TIMP-2在乳腺癌组织中的表达及意义 |
| Expressions and Significances of MMP-2, MMP-7, MMP-9, TIMP-1 andTIMP-2 mRNAs in the Breast Cancer |
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| DOI： |
| 中文关键词: 基质金属蛋白酶 基质金属蛋白酶抑制剂 乳腺癌 浸润转移 |
| 英文关键词: MMPs TIMPs Breast cancer Infiltration and metastasis |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨基质金属蛋白酶及其抑制剂在乳腺癌组织中的表达及其与肿瘤浸润转移的关系，为乳腺癌的临床治疗及预后预
测提供基础。方法：选择我院2012 年5 月至2014 年5 月收治的乳腺癌患者80 例，对所选病例的乳腺癌组织、癌旁组织及正常乳
腺组织样本进行检测。观察并比较不同乳腺组织中MMP-2，MMP-7、MMP-9、TIMP-1 及TIMP-2 mRNA 的表达水平。结果：与正常
乳腺组织相比较，乳腺癌组织和癌旁组织中MMP-2、MMP-7、MMP-9，TIMP-1 及TIMP-2 mRNA 的表达显著增加，差异具有统计
学意义(P<0.05)。乳腺癌组织中MMP-2、MMP-7、MMP-9、TIMP-1 及TIMP-2 mRNA 的表达显著高于癌旁组织和正常组织，差异具
有统计学意义(P<0.05)。随着肿瘤范围扩大，MMP-2、MMP-7 和MMP-9 mRNA 的表达水平显著增加(P<0.05)，而TIMP-1 和
TIMP-2 mRNA 表达无显著变化(P>0.05)。随着淋巴结转移进展，MMP-2、MMP-7 和MMP-9 mRNA的表达显著增加(P<0.05)，而
TIMP-1 和TIMP-2 mRNA无显著变化(P>0.05)。结论：MMP-2、MMP-7、MMP-9、TIMP-1 和TIMP-2 的mRNA 在乳腺癌组织中呈
高表达，这可能与乳腺癌的发生和发展有关，而MMP-2、MMP-7 和MMP-9 可能有助于预测乳腺癌的侵袭行为。 |
| 英文摘要: |
| Objective:To explore the expressions of MMPS and TIMPs in the tissues of breast cancer and their relationships with
tumor metastasis in order to provide references for the treatment and prognostic prediction of breast cancer.Methods:80 patients with
breast cancer who were treated in our hospital from May 2012 to May 2014 were selected. Then the mRNA expressions of MMP 2,
MMP-7, MMP-9, TIMP 1 and TIMP-2 in breast cancer, para-carcinoma tissue and normal breast tissues were detected and compared.Results:Compared with that in the normal breast tissues, the mRNA expressions of MMP 2, MMP-7, MMP-9, TIMP 1 and TIMP-2 in
the breast cancer and para-carcinoma tissue were all significantly increased (P<0.05). The mRNA expressions of MMP 2, MMP-7,
MMP-9, TIMP-1 and TIMP-2 in the breast cancer tissues and the para-carcinoma tissue were significantly higher than those of the control
group(P<0.05). With the increase of tumor range, the mRNA expression of MMP-2, MMP-7 and MMP-9 were all significantly increased
(P<0.05), and no significant difference was found in the mRNA expression of TIMP-1 and TIMP-2 (P>0.05). With the progression of
lymph node metastasis, the mRNA expressions of MMP-2, MMP-7 and MMP-9 were all significantly increased (P<0.05), and no
significant difference was found in the mRNA expression of TIMP-1 and TIMP-2 (P>0.05).Conclusion:MMP 2, MMP-7, MMP-9 and
TIMP 1 and TIMP-2 mRNA were highly expressed in breast cancer tissue, which could be closely related to the occurrence and development
of breast cancer. MMP 2, MMP-7 and MMP-9 may be useful for the prediction of infiltration and metastasis of breast cancer. |
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