| 宫柏琪 高凌根 马晶莹 曹甜甜 张琳.阿托伐他汀钙对无动脉硬化原发性高血压患者血脂和颈动脉内膜
中层厚度的影响[J].现代生物医学进展英文版,2015,15(15):2941-2943. |
| 阿托伐他汀钙对无动脉硬化原发性高血压患者血脂和颈动脉内膜
中层厚度的影响 |
| Influence of Atorvastatin Calciumon Blood Lipids and Carotid ArteryIntima-Media Thickness in Patients with No Arteriosclerosis of PrimaryHypertension |
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| DOI： |
| 中文关键词: 阿托伐他汀钙 高血压 血脂 颈动脉内膜中层厚度 |
| 英文关键词: Atorvastatin calcium Hypertension Blood lipids Carotid artery intima-media thickness |
| 基金项目: |
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| 中文摘要: |
| 目的：研究阿托伐他汀钙对无动脉硬化原发性高血压患者血脂和颈动脉内膜中层厚度（calMT）的影响。方法：选取2013 年7
月到2014 年7 月我院收治的无动脉硬化原发性高血压患者100 例，按照随机数字表法将患者分为研究组和对照组，每组50 例，
对照组给予常规治疗，研究组在对照组的基础上给予阿托伐他汀钙治疗，治疗时间均为6 个月。比较治疗前、治疗后两组血脂、血
压以及calMT。结果：研究组治疗后总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）显著降低，高密度脂蛋白胆固醇（HDL-C）显著
增高，且显著优于对照组治疗后，比较差异具有统计学意义（P＜0.05）；两组治疗后血压均显著低于治疗前，比较差异具有统计学
意义（P＜0.05），且治疗后研究组显著优于对照组，比较差异具有统计学意义（P＜0.05）；治疗后研究组calMT显著优于治疗前，且
优于对照组，比较差异具有统计学意义（P＜0.05）。结论：阿托伐他汀钙治疗无动脉硬化原发性高血压能显著改善患者血脂水平，
降低其calMT，对预防患者动脉粥样硬化具有重要意义。 |
| 英文摘要: |
| Objective:To study the influence of atorvastatin calcium on blood lipids and carotid artery intima-media thickness
(calMT) in patients with no arteriosclerosis of primary hypertension.Methods:Selected 100 cases of patients with no arteriosclerosis of
essential hypertension who were treated in our hospital from July 2013 to July 2014, they were divided into study group and control
group with 50 patients in each group according to the randomnumber table method, control group was treated with conventional therapy,
while the study group was added the atorvastatin calciumon the basis of control group therapy, the course of treatment in two groups was
6 months. Compared blood lipids, blood pressure and calMT in two groups before and after treatment.Results:Total cholesterol(TC),
low density lipoprotein cholesterol(LDL-C) of study group after treatment were significantly reduced, while their high density lipoprotein
cholesterol (HDL-C) was significantly increased, which were significantly better than control group after treatment,the differences were
statistically significant (P<0.05); The blood pressure of two groups after treatment were significantly lower than before treatment, the
differences were statistically significant (P<0.05), and the study group was significantly better than the control group after treatment, the
difference was statistically significant (P<0.05); CalMT of study group after treatment was significantly better than before treatment, and
better than control group after treatment, the differences were statistically significant (P<0.05).Conclusion:Atorvastatin calcium can significantly
improve the blood lipids and reduce the calMT in treating no arteriosclerosis of essential hypertension, which has an important
significance in the prevention of atherosclerosis. |
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