| 陈熙军 胡开洪 鲁毅 毛晓琴 杨岳.左卡尼汀联合蔗糖铁对血液透析患者肾性贫血及氧化应激的影响[J].现代生物医学进展英文版,2015,15(15):2907-2909. |
| 左卡尼汀联合蔗糖铁对血液透析患者肾性贫血及氧化应激的影响 |
| Effect of L-carnitine and Iron Sucrose on Renal Anemia and Oxidative Stressin Hemodialysis Patients |
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| DOI： |
| 中文关键词: 氧化应激 肾性贫血 蔗糖铁 左卡尼汀 |
| 英文关键词: Oxidative stress Renal anemia Iron sucrose L-carnitine |
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| 中文摘要: |
| 目的：探讨左卡尼汀联合蔗糖铁对血透患者肾性贫血及氧化应激的影响。方法：抽选我院2010 年3 月-2013 年5 月行维持
血透治疗的肾性贫血患者79 例，采用数字表法分为对照组（39 例）和观察组（40 例），对照组采用促红细胞生成素（EPO）、单用蔗
糖铁及常规对症治疗，观察组在对照组基础上联用左卡尼汀治疗。比较两组患者治疗前、治疗6 个月后血红蛋白(Hb)、血细胞比容
（Hct）、血浆铁蛋白(SF)、转铁蛋白饱和度(TSAT)、晚期蛋白质氧化产物(AOPP) 及血丙二醛(MDA)水平，并对两组治疗开始时、治
疗3、6 个月时EPO 使用剂量进行比较。结果：治疗6 个月后，观察组患者Hb、Hct、SF、TSAT 明显高于对照组（P<0.05），AOPP、
MDA明显低于对照组（P<0.05）；对照组从治疗开始到治疗6 个月时一直维持较高的EPO 使用剂量，而观察组EPO 用量依次递
减，至治疗6 个月时EPO用量显著低于对照组（P<0.05）。结论：左卡尼汀能联合蔗糖铁治疗肾性贫血的疗效显著，能有效缓解氧
化应激反应，降低EPO用量，值得临床推广。 |
| 英文摘要: |
| Objective:To explore the impact of L-carnitine and iron sucrose on renal anemia and oxidative stress in hemodialysis
patients.Methods:79 cases of patients with renal anemia who treated in our hospital and underwent maintenance hemodialysis treatment
fromMarch 2010 to May 2013 were selected, they were randomly divided into control group (39 cases) who used erythropoietin (EPO),
single iron sucrose and conventional symptomatic treatment and observation group (40 cases) who added with L-carnitine treatment on
the basis of the control group. Compared the hemoglobin (Hb), hematocrit (Hct), plasma ferritin (SF), transferrin saturation (TSAT), advanced
oxidation protein products (AOPP) and serum malondialdehyde (MDA) level of two groups before treatment and after 6 months
treatment, and compared the use of EPO dose at the beginning of treatment and after treatment for 3, 6 months.Results:After 6 months
treatment, Hb, Hct, SF, TSAT of observation group were significantly higher than those in control group (P<0.05); AOPP, MDA was significantly
lower than that of the control group (P<0.05). The control group maintained a high dose of EPO from the beginning of treatment
and after treatment for 6 months, and the treatment group was reduced, it was significantly lower than that of control group after
treatment for 6 months (P<0.05).Conclusion:L-carnitine combined with iron sucrose in treatment of renal anemia has significantly effect,
can effectively alleviate the oxidative stress reaction, reduce the use of EPO dose, which is worthy of clinical application. |
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