| 管楠 王文倩 徐玉东 王宇 尹磊淼 杨永清.肌动蛋白结合蛋白2 (Transgelin-2)生物学特性和功能研究进展[J].现代生物医学进展英文版,2015,15(14):2774-2776. |
| 肌动蛋白结合蛋白2 (Transgelin-2)生物学特性和功能研究进展 |
| Advances in Biological Characteristics and Functions of Transgelin-2 |
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| DOI： |
| 中文关键词: Transgelin-2 蛋白特性 亚细胞定位 生物学功能 |
| 英文关键词: Transgelin-2 Protein characteristics Subcellular localization Biological function |
| 基金项目:国家自然科学基金项目(81173341；81173332；81473760；81202753)；上海市卫生系统优秀青年人才培养计划(XYQ2013081)；
上海市中医药事业发展三年行动计划重大研究项目(ZYSNXD-CC-ZDYJ039) |
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| 中文摘要: |
| 肌动蛋白结合蛋白是指能与肌动蛋白的单体、多聚体等结合的蛋白，肌动蛋白结合蛋白2(Transgelin-2)作为一种重要的肌
动蛋白结合蛋白，可广泛分布在平滑肌细胞及非平滑肌细胞。Transgelin-2 基因可广泛表达在全身各组织器官，其在亚细胞层面上
有多种定位，且在不同病理生理状态下可能存在定位转移。Transgelin-2 蛋白被认为参与了多种恶性肿瘤疾病，可能是特异性肿瘤
标志物。本文对Transgelin-2 蛋白的特性、亚细胞定位和相应生物学功能进行了综述，以期为相关机制研究提供可能的判断依据。 |
| 英文摘要: |
| Actin-binding protein is a protein that can combine with the actin monomer, polymer and other proteins. As an
important actin-binding protein, actin-binding protein2 (Transgelin-2) can distribute in the smooth muscle cells and non-smooth muscle
cells. Transgelin-2 gene is widely expressed in various tissues and organs of the body, which is positioned on a variety of sub-cellular
level, and it may be shifted position at different pathophysiological states. Transgelin-2 protein may be a specific tumor marker and is
believed to participate in a variety of malignant diseases. In order to provide a possible reference for the relevant mechanism research, the
characteristics of Transgelin-2 protein, subcellular localization and the corresponding biological functions were reviewed in this paper. |
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