| Objective:To study the effect of glutamine on intestinal mucosal barrier function and immune function in septic
patients.Methods:40 cases of sepsis patients who were treated in our hospital from October 2012 to October 2013 were randomly
divided into treatment group and control group, and 20 cases were in each group. Two groups were given conventional symptomatic
treatment, the treatment group received glutamine treatment and the control group received a placebo. The serumD-lactic acid levels was
detected by spectrophotometry,and urinary lactulose / mannitol (L/M) value was detected by High performance liquid chromatography.
Indexes of intestinal mucosal barrier function, immune function and the incidence of ARDS, MODS were compared between two groups.Results:After treatment, the incidence of ARDS, MODS of treatment group were 24.1%, 17.2%, lower than those of the control group
(38.9%, 33.3%), the difference was statistically significant (P<0.05); At 14 days after treatment, the D-lactic acid level and the urinary
L/M level in treatment group were significantly lower than those of the control group,and serum IgG, IgM, CD4+ and CD4+/CD8+
increased significantly.Conclusion:Glutaminecan significantly improve the intestinal mucosal barrier function, and promote the immune
function and nutritional status in treatment of sepsis patients, it can also reduce the translocation of intestinal bacteria and endotoxin. |
