| 樊琳琳 于吉祥 吴君丽 卢颖 李园园.Leptin、TNF-alpha、FFA 在肥胖症患者血清中的表达及临床意义[J].现代生物医学进展英文版,2015,15(14):2727-2729. |
| Leptin、TNF-alpha、FFA 在肥胖症患者血清中的表达及临床意义 |
| The Expression and Clinical Significance of SerumLeptin, TNF- alpha,FFA in Patients of Obesity |
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| DOI： |
| 中文关键词: 瘦素 肿瘤坏死因子alpha 游离脂肪酸 肥胖 |
| 英文关键词: Leptin Tumor necrosis factor-alpha Free fatty acids Obesity |
| 基金项目: |
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| 中文摘要: |
| 目的：研究瘦素（Leptin）、肿瘤坏死因子alpha（TNF-alpha）和游离脂肪酸（FFA）在肥胖患者血清中的表达以及其临床意义。方法：选
取2013 年5 月到2014 年5 月我院体检的肥胖症患者30 例（研究组），另选取非肥胖症者30 例（对照组），测量两组空腹血糖
（FPG）、空腹胰岛素（FINS）、血脂和Leptin、TNF- alpha、FFA 等指标，并比较两组之间的差异，观察Leptin、TNF- alpha、FFA 和肥胖相关指
标的相关关系。结果：研究组甘油三脂（TG）、极低密度脂蛋白- 胆固醇（VLDL-C）、Leptin、FINS 、FPG、TNF- alpha、FFA 以及HOMA
模型胰岛素抵抗指数（HOMA-IR）分别为（1.98± 0.31）mmol/L、（0.76± 0.02）mmol/L、（15.14± 0.04）ug/L、（20.56± 0.04）mmol/L、
（5.93± 0.04）mmol/L、（43.98± 0.14）ng/L、（0.17± 0.01）mmol/L 和（5.37± 0.25）均显著高于对照组，两组比较差异具有统计学意
义（t=9.423，8.979，9.074，10.082，9.089，9.562，9.065，10.083，均P＜0.05）；研究组胰岛素敏感指数（ISI）为（0.011± 0.002）显著低于
对照组（0.021± 0.001），两组比较差异具有统计学意义（t=11.428，P=0.012）；FFA 与TG、HOMA-IR、FINS 呈正相关关系（r=0.
842，0.796，0.879，P=0.017.0.019，0.023），与ISI 呈负相关关系（r=-0.958，P=0.021）；Leptin 与BMI、HOMA-IR、FINS 呈正相关关系
（r=0.793，0.869，0.837，P=0.018，0.022，0.017），与ISI 呈负相关关系（r=-0.905，P=0.011）；TNF-alpha与ISI 呈负相关关系（r=-0.807，
P=0.013）。结论：肥胖者血清中Leptin、TNF- alpha、FFA 显著高于正常者，且和肥胖等项指标具有相关关系。 |
| 英文摘要: |
| Objective:To study the expression and clinical significance of serum Leptin, TNF-alpha,FA in obesity patients.Methods:30 cases of obesity were selected fromour hospital fromMay 2013 to May 2014(the study group), 30 cases of non-obesity were
also selected as the control group, the fasting plasma glucose (FPG), fasting insulin (FINS), lipids and Leptin, TNF-琢, FFA and other
indicators of two groups were measured and compare between the two groups, correlation between Leptin, TNF-alpha, FFA and
obesity-related indicators were observed.Results:The levels of triglyceride (TG), very low density lipoprotein-cholesterol (VLDL-C),
Leptin, FINS, FPG, TNF- alpha, FFA and HOMA model of insulin resistance index (HOMA-IR) of the study group were (1.98± 0.31)
mmol/L, (0.76± 0.02) mmol/L, (15.14± 0.04) ug/L, (20.56± 0.04) mmol/L, (5.93± 0.04) mmol/L, (43.98± 0.14) ng/L, (0.17± 0.01)
mmol/L and (5.37± 0.25), significantly higher than those of the control group, the difference was statistically significant(t=9.423, 8.979,
9.074, 10.082, 9.089, 9.562, 9.065, 10.083 all P<0.05), the insulin sensitivity index (ISI) of the study group was （0.011 ± 0.002）
significantly lower than that (0.021± 0.001) of the control group, the difference was statistically significant (t=11.428, P=0.012); FFA
had positive correlations with TG, HOMA-IR and FINS (r=0.842, 0.796, 0.879, P=0.017.0.019, 0.023), while had a negative correlation
with ISI (r=-0.958, P=0.021); Leptin had a positive correlation with BMI, HOMA-IR and FINS (r=0.793, 0.869, 0.837, P=0.018, 0.022,
0.017), and a negative correlation with ISI (r=-0.905, P=0.011); TNF-alpha and ISI were negatively correlated (r= -0.807, P=0.013).Conclusion:The serumLeptin, TNF-alpha and FFA are significantly higher in obesity, and had correlation with other obesity indexes. |
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