| 岳建宏 邢建峰 田莉 官清 郭萍.药学角度探讨和分析不同来源卵泡刺激素对体外受精-胚胎移植结局的影响[J].现代生物医学进展英文版,2015,15(14):2723-2726. |
| 药学角度探讨和分析不同来源卵泡刺激素对体外受精-胚胎移植结局的影响 |
| Influence of Follicle Stimulating Hormone fromDifferent Sourceson the Outcome of Vitro Fertilization-embryo Transfer:froman Pharmacy Point of View |
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| DOI： |
| 中文关键词: 高纯度尿源性卵泡刺激素(HP-uFSH） 基因重组FSH 控制性促排卵 药学 妊娠结局 |
| 英文关键词: High pure urine derived FSH (HP-uFSH) Recombinant FSH (r-FSH) Controlled ovarian stimulation Pharmacy Pregnancy Outcome |
| 基金项目: |
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| 中文摘要: |
| 目的：比较基因重组卵泡刺激素(r-FSH)及高纯度尿源性卵泡刺激素(HP-uFSH）对体外受精－胚胎移植(IVF-ET)妊娠结局的
影响，结合临床表现从药学角度探讨和分析。方法：回顾分析具IVF/单精子卵细胞浆内显微注射授精(ICSI)指诊并首次接受IVF/ICSI
助孕的不孕症患者235 例,以给予的FSH 药物种类不同分为2 组：HP-uFSH 组（n=135)和r-FSH 组(n=100)。主要研究指标为出生
率,次要研究指标为临床妊娠率,流产率及着床率。结果：HP-uFSH组外源性促性腺激素(Gn)总量和FSH 量均多于r-FSH 组(P<0.
01)，获卵数和可移植胚胎数较r-FSH 组少(P<0.01），受精率较r-FSH 组低（P<0.05）。两组平均Gn 刺激天数，妊娠结局及中重度卵
巢过度刺激综合征(OHSS)发生率均无统计学差异(P>0.05）。对患者年龄<35 岁和≥ 35 岁分别进行分组发现，年龄<35 岁患者中
的HP-uFSH 组较r-FSH 组平均年龄更大，不孕年限更长，基础窦卵泡数（AFC）更少(P<0.01），≥ 35 岁患者中的HP-uFSH 组与
r-FSH组的基本特征（年龄，不孕年限，AFC）无统计学差异(P>0.05)；无论年龄<35 岁或年龄≥ 35 岁，HP-uFSH组的Gn 量和FSH
量较r-FSH 组均更大，获卵数及可移植胚胎数更少(P<0.01)。结论：在IVF/ICSI周期治疗中，国产HP-uFSH 与r-FSH进行COS 具
有等同的IVF临床妊娠率及出生率。 |
| 英文摘要: |
| Objective:To compared the influence of recombinant follicle stimulating hormones(r-FSH)and high pure urine derived
FSH(HP-uFSH) on the outcome of vitro fertilization-embryo transfer(IVF-ET), and combined the clinical manifestation to investigate and
analyze their effect from an pharmacy point of view.Methods:Retrospectively analyzed 235 cases of infertility who were accepted
assisted reproduction first time by IVF/intracytoplasmic sperm injection (ICSI). They were divided into HP-uFSH group (n=135) and
r-FSH group (n=100) according to the corresponding FSH.Birth rate was the main research index, and clinical pregnancy rate, abortion
rate and implantation rate were the secondary ones.Results:Total exogenous gonadotropin (Gn) and FSH amount of HP-uFSH group
were significantly higher than r-FSH group(P<0.01), however, oocytes amount and transferable embryos amount of HP-uFSH group were
significantly less than r-FSH group (P<0.01), and the fertility rate was significantly lower than r-FSH group (P<0.05). Average Gn
stimulation days, pregnancy outcomes and incidence of ovarian hyperstimulation syndrome (OHSS) of two groups had no significant
difference(P>0.05). Regarding to the patients<35 and ≥ 35 years old, we found the average age was older, infertility years was longer and
basic antral follicle (AFC) was lower in HP-uFSH group compared with r-FSH group in patients<35 years old (P<0.01), while above
indexes were no significant differences in patients≥ 35 years old(P>0.05), total Gn and FSH amount were higher and oocytes amount and
transferable embryos amount were less in HP-uFSH group compared with r-FSH group both in patients<35 and ≥ 35 years old(P<0.01).Conclusion:Domestic HP-uFSH and r-FSH implement COS has the similar clinical pregnancy rate and birth rate of IVF in the treatment
of IVF/ICSI. |
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