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付振李觅崔翔刘庆孔祥复.女性甲状腺癌的病理与预后分析[J].现代生物医学进展英文版,2015,15(14):2703-2706.

女性甲状腺癌的病理与预后分析

Pathology and Prognosis of Female Patients with Thyroid Carcinoma

DOI：

中文关键词: 甲状腺癌女性患者病理临床预后

英文关键词: Thyroid carcinoma Female patients Pathology Clinical outcomes

基金项目:重庆市自然科学基金项目（cstc2012jjys10001）

Author Name	Affiliation
付振李觅崔翔刘庆孔祥复	解放军第三军医大学西南医院病理科；解放军第三军医大学西南医院心内科；解放军第三军医大学西南医院乳腺科

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中文摘要:

目的：探讨女性甲状腺癌的病理特点以及预后影响因素。方法：收集2005年1 月至2009 年8 月，齐齐哈尔和平医院收治的女性甲状腺癌患者148 例，回顾分析其临床病理特点以及预后影响因素。结果：病理检查显示131 例（88.5%）甲状腺乳头状癌（PTC），6 例（4.1%）为滤泡状癌（FTC），3 例（2.0%）为髓样癌（MTC），6 例（4.1%）为未分化癌（ATC）；病理分期Ⅰ-Ⅱ期占45.3%，Ⅲ -Ⅳ期占54.7%；27 例（18.24%）为周围组织侵犯，9 例(6.1%)为远处转移，10 例（6.76%）对侧甲状腺转移，56 例（37.84%）颈部淋巴结转移；1 年、3 年、5 年生存率依次为97.3%、93.2%、83.8%；年龄、病理床分期、病理类型、淋巴结转移、远处转移以及周围组织侵犯均是影响临床预后的重要因素（P<0.05）。结论：女性甲状腺癌存在病理分期晚、病理分型差、淋巴结转移、远处转移及局部侵犯率高等不良预后因素，早期影像学检查对临床治疗具有指导意义。

英文摘要:

Objective:To investigate the pathological features and the prognostic factors of female patients with thyroid carcinoma.Methods:148 cases of female patients with thyroid carcinoma in our hospital between January 2008 and August 2009 were collected, and the clinicopathological characteristics and prognostic factors were retrospectively analyzed.Results:Pathological examination showed that 131 cases (88.5%) were papillary thyroid carcinoma (PTC), 6 patients (4.1%) were follicular carcinoma (FTC), 3 cases (2.0%) were medullary carcinoma (MTC), 6 patients (4.1%) were undifferentiated carcinoma (ATC); pathological stage Ⅰ -Ⅱ period accounted for 45.3%, Ⅲ -Ⅳ stage accounted for 54.7%; 27 cases (18.24%) of surrounding tissue invasion, 9 cases (6.1%) of distant metastases, 10 cases (6.76%) of contralateral thyroid metastases, 56 cases (37.84%) of cervical lymph node metastasis; 1-year, 3-year, 5-year survival rates were 97.3%, 93.2%, 83.8%. Age, pathological bed staging, histological type, lymph node metastasis, distant metastasis and surrounding tissue invasion were the important clinical prognostic factors (P<0.05).Conclusion:Female patients with thyroid carcinoma have adverse prognostic factors of late staging, serious pathological type, high lymph node metastasis, distant metastasis and local invasion rate, and the early imaging examination is important for guide of clinical treatment.

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