| 张书卿 张博 洪亮 周永安 张裘 易受乡.顺铂联合针灸疗法对晚期肺癌患者血清CSF、TNF-alpha与IL2水平的影响[J].现代生物医学进展英文版,2015,15(14):2689-2691. |
| 顺铂联合针灸疗法对晚期肺癌患者血清CSF、TNF-alpha与IL2水平的影响 |
| Effect of Cisplatin Plus Acupuncture on the SerumCSF, TNF-alpha and IL-2levels of Patients with Lung Cancer |
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| DOI： |
| 中文关键词: 晚期肺癌 顺铂 针灸 集落刺激因子 肿瘤坏死因子 白细胞介素2 |
| 英文关键词: e stage lung cancer Cisplatin plus acupuncture CSF TNF-alpha IL2 |
| 基金项目: |
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| 中文摘要: |
| 目的：探究顺铂联合针灸疗法对晚期肺癌患者血清集落刺激因子(CSF)、肿瘤坏死因子(TNF-alpha)与白细胞介素2(IL2)水平的
影响。方法：选取我院肿瘤科收治的晚期肺癌患者60 例，并将其随机分为对照组和实验组。对照组30 例患者仅予顺铂常规治疗；
实验组30 例患者顺铂在常规治疗的基础上加用针刺肺俞、丰隆、中府、太渊、尺泽、心俞、天宗、膻中、膏肓、尺泽、背压痛点、灸丹
田穴位。治疗前后，检测和比较两组患者的血清CSF、TNF-alpha与IL2 水平。结果：治疗前，两组患者的血清CSF、TNF-alpha、IL2 水平比
较均无统计学差异(P>0.05)；治疗后，两组的血清CSF、TNF-alpha、IL2水平均较治疗前降低，且实验组显著低于对照组，差异均有统计
学意义(P＜0.05)。实验组的治疗总有效率明显高于对照组，脱发、失眠、白细胞减少的发生率均明显低于对照组，差异均具有统计
学意义(P＜0.05)。结论：顺铂联合针灸治疗能够明显降低晚期肺癌患者的血清CSF、TNF-alpha与IL2 水平，进而可能提高患者的免疫
功能和临床疗效，值得临床进一步研究和推广应用。 |
| 英文摘要: |
| Objective:To explore the effect of cisplatin combined with acupuncture therapy on the colony stimulating factor(CSF),
tumor necrosis factor-alpha (TNF-alpha) and interleukin 2 (IL2) levels in patients with advanced lung cancer.Methods:60 patients with
advanced lung cancer admitted in our hospital oncology were selected and randomly divided into two groups, 30 cases given cisplatin
routine therapy were divided into the control group, while the other 30 cases in experimental group were treated with acupuncture therapy
on the basis of conventional treatment. Then the serum levels of CSF, TNF-alpha and IL2 were compared between two groups before and
after treatment.Results:Before treatment, no statistical difference was found in the serum CSF, TNF-alpha, IL2 levels between two groups
(P>0.05). After treatment, the serum CSF, TNF-alpha, IL2 levels of experimental group were significantly lower than those of the control
group (P<0.05). The total efficacy of experimental group was better than that of the control group, while the incidence rates of adverse
reactions such as hair loss, insomnia, leukopenia were all lower than those of the control group (all P<0.05).Conclusion:Cisplatin plus
acupuncture could obviously lower the serum CSF, TNF-alpha , IL2 levels of patients with advanced lung cancer, which may contribute to
improve the immune function and clinical efficacy and was worth being further studied and popularized in clinic. |
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