| 刘梅玲 卢兰敏 郭惠萍 冯丹.老年2 型糖尿病患者发生严重低血糖相关危险因素分析[J].现代生物医学进展英文版,2015,15(13):2518-2521. |
| 老年2 型糖尿病患者发生严重低血糖相关危险因素分析 |
| Study on Related Risk Factors of Severe Hypoglycemia in Elderly Type 2Diabetes Mellitus Patients |
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| DOI： |
| 中文关键词: 老年2 型糖尿病 严重低血糖 危险因素 |
| 英文关键词: Elderly type 2 diabetes mellitus Severe hypoglycemia Risk factor |
| 基金项目:国家自然科学基金项目（30901795） |
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| 中文摘要: |
| 目的：研究老年2 型糖尿病患者发生严重低血糖的相关危险因素。方法：选取2013 年7 月到2014 年7 月我院收治的老年2
型糖尿病患者200 例，根据是否发生严重低血糖将患者分为非低血糖组（138 例）和低血糖组（62 例），比较两组临床资料。结果：
低血糖组和非低血糖组体重指数、住院时间以及糖尿病病程比较差异具有统计学意义（P＜0.05）；低血糖组心脑血管疾病药物联
用率显著高于非低血糖组，二甲双胍应用率显著低于非低血糖组，胰岛素应用率以及口服降糖药（OAD）和胰岛素的联合应用率
显著高于非低血糖组，两组比较差异具有统计学意义（P＜0.05）；低血糖组低钾血症发生率显著高于非低血糖组，肾功能有关的指
标显著高于非低血糖组，低血糖组白细胞和中性粒细胞显著高于非低血糖组，两组比较差异具有统计学意义（P＜0.05）；Logistic
多因素回归分析可知，病程超过10 年、胰岛素应用以及和OAD联用、果糖胺低于2.5 mmol/L、白细胞升高、肾功能受损均和严重
低血糖发生具有相关关系。结论：病程超过10 年、胰岛素应用以及和OAD联用、白细胞升高、果糖胺低于2.5 mmol/L、肾功能受
损均和严重低血糖发生有关，在行降糖治疗时应该谨慎评估上述危险因素。 |
| 英文摘要: |
| Objective:To study the risk factors related to the occurrence of severe hypoglycemia in elderly type 2 diabetes mellitus
(T2DM) patients.Methods:200 elderly T2DMpatients admitted in our hospital from Jul 2013 to Jul 2014 were enrolled and divided into
non-hypoglycemia group (n=138) and hypoglycemia group (n=62) according to whether they developed severe hypoglycemia or not. The
clinical materials of the two groups were compared.Results:The differences of BMI, hspitalization and course of disease between the
two groups were statistically significant (P＜0.05). The combination rate of cardiovascular and cerebrovascular drugs, utility rate of melbine,
insulin, and the combined of oral hypoglycemic drugs (OAD) and insulin in hypoglycemia group was significantly higher, lower,
higher and higher, respectively, than those of the non-hypoglycemia group (P＜0.05). The occurrence rate of hypokalemia in hypoglycemia
group was obviously higher than that of the non-hypoglycemia group, and the renal function indicators, white cells, and neutrophile
granulocytes in hypoglycemia group were all higher than those of the non-hypoglycemia group with statistically significant differences
(P＜0.05). Logistic multi-factor regression analysis showed that over 10 years of disease course, application of insulin, combined
use of OAD, less than 2.5 mmol/L of froctosamine, increase of white cells and impairment of renal function were all related to the occurrence
of severe hypoglycemia.Conclusion:Over 10 years of disease course, application of insulin, combined use of OAD, less than 2.5
mmol/L of froctosamine, increase of white cells and impairment of renal function were all associated with the incidence of severe hypoglycemia.
Those factors should be carefully taken into consideration when giving hypoglycemic therapy. |
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