| 杨忠路 刘涛 张仁腾 姜辉 王辉山△.ET-1 与NT-proBNP浓度变化对高血压左心室肥厚的诊断价值[J].现代生物医学进展英文版,2015,15(13):2512-2514. |
| ET-1 与NT-proBNP浓度变化对高血压左心室肥厚的诊断价值 |
| Diagnostic Value of Plasma ET-1 and NT-proBNP of Patients withHypertensive Left Ventricular Hypertrophy |
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| DOI： |
| 中文关键词: 血浆ET-1 NT-proBNP 高血压 左心室肥厚 |
| 英文关键词: Plasma ET-1 NT-proBNP Hypertension Left ventricular hypertrophy |
| 基金项目:辽宁省科学技术计划项目（2013225089） |
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| 中文摘要: |
| 目的：探讨高血压左心室肥厚（Left ventricular hypertrophy，LVH）患者血浆内皮素（Endothelin，ET-1）、氨基末端脑钠肽前体
（N-terminal pro brain natriuretic peptide，NT-proBNP）的浓度变化及其诊断价值。方法：收集2011 年3 月-2013 年5 月我医院确诊
为高血压LVH患者128 例设为观察组，选取同期128 例体检正常人作为对照组。分析比较两组ET-1、NT-proBNP的浓度。结果：
观察组血浆NT-proBNP 及ET-1 浓度分别为（6.4± 3.5）pg/mL 和（18.4± 1.5）pg/mL，显著高于对照组，差异有统计学意义（P＜
0.05）；ROC图显示，NT-proBNP 曲线下面积为0.932，可信区间为0.886-0.988，灵敏度为97.8%，特异度为79.9%；血浆ET-1 曲线
下面积为0.798，可信区间为0.709-0.892，灵敏度为65%，特异度为93.1%。结论：高血压LVH患者NT-proBNP 及血浆ET-1 水平
显著高于正常人，对高血压LVH 患者NT-proBNP及血浆ET-1 的诊断具有重要意义。 |
| 英文摘要: |
| Objective:To investigate the concentration and its diagnostic value of endothelin (ET-1), N-terminal pro brain natriuretic
peptide (NT-proBNP) in plasma of hypertensive left ventricular hypertrophy (LVH) patients.Methods:128 cases of hypertension
patients with LVH fromMarch 2011 to May 2013 in our hospital were enrolled as the observation group, and 128 cases of healthy people
during the same period were selected as control group. The plasma concentration of ET-1, NT-proBNP was tested using enzyme-linked
immunosorbent assay.Results:The plasma concentration of NT-proBNP and ET-1 in observation group was (6.4± 3.5) (pg/mL) and
(18.4 ± 1.5) (pg/mL) respectively, significantly higher than that of the control group (P＜0.05). The area under the ROC curve of
NT-proBNP in LVH diagnosis was 0.932, with the confidence interval between 0.886 and 0.988, the sensitivity of 97.8% and specificity
of 79.9%. The area under the ROC curve of plasma ET-1 in LVH diagnosis was 0.798, with the confidence interval between 0.709 and
0.892, and a sensitivity of 65% and specificity of 93.1%.Conclusion:The plasma level of NT-proBNP and ET-1 of LVH patients with
hypertension was significantly higher than that in healthy subjects, which is significant to the diagnosis of LVH patients with hypertension. |
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