| 尤振宇 刘洋 苏晓辉 刘渤娜 刘学飞.全反式维甲酸联合化疗治疗晚期结肠癌临床观察[J].现代生物医学进展英文版,2015,15(13):2478-2482. |
| 全反式维甲酸联合化疗治疗晚期结肠癌临床观察 |
| Clinical Observation on Chemotherapy Plus All-trans Retinoid Acid in theTreatment of Advanced Colon Carcinoma |
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| DOI： |
| 中文关键词: 晚期结肠癌 化疗 全反式维甲酸 临床疗效 疾病进展时间 |
| 英文关键词: Advanced colon carcinoma Chemotherapy All-trans retinoid acid Curative efficacy Time to progress |
| 基金项目:辽宁省科学技术计划项目（2013225089） |
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| 中文摘要: |
| 目的：探讨全反式维甲酸联合化疗治疗晚期结肠癌的临床疗效和安全性。方法：将2009 年4 月至2012 年3 月我院收治的
178 例晚期结肠癌患者随机分入试验组(全反式维甲酸联合mFOLFOx6 方案化疗)和对照组(单纯mFOLFOx6 方案化疗)，每组89
例。治疗后，观察和比较两组患者的近期疗效、疾病进展时间、总生存期、KPS 评分改善情况和不良反应的发生情况。结果：试验组
的近期有效率为67.8%，对照组为50.6%，显著低于试验组(P=0.021)；试验组患者的KPS 评分改善率为79.3%，而对照组为
57.4%，显著低于试验组(P=0.002)。试验组患者的中位生存期和中位疾病进展期分别为14.784、7.502 个月；对照组患者分别为
13.12、6.244 个月，均较试验组显著缩短(P<0.05)。试验组患者恶心呕吐的发生率显著低于对照组(P=0.016)，两组其它不良反应如
骨髓抑制、肝肾功能损害、心脏毒性等的发生率比较差异无统计学意义(P>0.05)。结论：全反式维甲酸注射液联合化疗治疗晚期结
肠癌可以提高其临床疗效，延长其生存期，改善其生存质量，且能减轻消化道不良反应。 |
| 英文摘要: |
| Objective:To evaluate the clinical efficacy and safety of all-trans retinoid acid combined with chemotherapy in the
treatment of advanced colon carcinoma.Methods:One hundred and seventy-eight patients with advanced colon carcinoma who were
treated in our hospital from April 2009 to March 2012 were recruited in this study. They were randomly assigned into two groups: study
group (n=89; receiving all-trans retinoid acid plus mFOLFOx6) and control group(n=89; receiving mFOLFOx6). The short-term clinical
efficacy, time to progress (TTP) and overall survival (OS), change of Karnofsky performance status score and incidence of adverse reactions
were observed and compared between two groups.Results:The short-termresponse rates of study group and control group were respectively
67.8%, 50.6%, which was significantly lower in the control group than that of the study group (P=0.021). The improvement
rate of KPS score of study group was 79.3%, which was significantly lower than that of study group(57.4%, P=0.002). The median survival
time and median time to progress of study group were 14.784, 7.502 months, while those of control group were 13.12, 6.244 months,
which were both shorter than those of the study group(P<0.05). The prevalence of nausea/vomiting of study group was significantly lower
than that of control group (P=0.016). No significant difference was found in the other toxicity such as bone marrow suppression , liver
dysfunction, renal dysfunction, Heart toxic reaction between the two groups was not statistically significant (P>0.05).Conclusion:All-trans retinoid acid combined with chemotherapy could improve the clinical efficacy of advanced colon carcinoma, lead to a better
survival time, a superior quality of life and had less nausea/vomiting prevalence. |
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