| 郑博杨 侯金晓 李慧波 付钥钥 周晋.浅议与APL预后密切相关的因子[J].现代生物医学进展英文版,2015,15(12):2397-2400. |
| 浅议与APL预后密切相关的因子 |
| Factors Closely Associated with the Prognosis of APL |
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| DOI： |
| 中文关键词: 急性早幼粒细胞白血病 预后因素 FLT3 CD56 Fas 基因 |
| 英文关键词: Acute promyelocytic leukemia Prognostic factor FLT3 CD56 Fas Gene |
| 基金项目:中国博士后科学基金项目（2012M520772）；黑龙江省青年基金项目（QC2012C036） |
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| 中文摘要: |
| 急性早幼粒细胞白血病（APL）是急性髓系白血病（AML）的一种特殊亚型。近年来随着全反式维甲酸和三氧化二砷的靶向
治疗日益规范化，APL的预后已很大程度上得到提高，成为AML 中预后最好的亚型，但仍有15%的患者发生复发。越来越的学者
致力于研究影响APL 预后的因素，以往很多人们关注过的因子在近来的研究中也发现在APL 中起着重要的作用，如FLT3、
CD56、Fas 等，以及新近证实的一些特殊基因的表达也影响着APL的预后，BAALC 低表达与APL 预后正相关，与其相反Ets 相
关基因（ERG）高表达与APL预后负相关。在此本文总结了近年来人们在APL预后研究的进展，这些因素的发现，使人们对APL
发病机制有了更深一层的了解，便于临床上早期对APL患者进行危险分层，对高风险的APL患者采用个体化治疗，也可成为日
后治疗APL的新靶点。 |
| 英文摘要: |
| Acute promyelocytic leukemia(APL) is a special type of acute myeloid leukemia(AML). Since all-trans retinoic acid
(ATRA) and arsenic trioxide have been used in APL successfully, the prognosis of APL has improved a lot, which makes it the best type
of leukemia, but there are still 15% patients to whom relapse may occur. More and more people focus on the factors which affect the
prognosis of APL. They have found many factors known to us before now play an important role in APL, for example: FLT3, CD56, Fas.
A lot of genes also affect the prognosis of this disease. Low BAALC expression has been shown to be associated with a superior outcome
in APL, on the contrary, high ERG expression maintained its value as an independent negative prognostic factor of APL. Here we
summarize the progress people have made these years. These findings help us to understand the pathogenesis of APL, to improve risk
classification in APL and to develop more individualized treatment strategies for high-risk APL patients, and in the future they may
become the new therapeutic targets. |
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