| Objective:To investigate the clinical significance of blood Homocysteine levels measured in process of Levodopa
Treatment of Parkinson's disease (PD).Methods:50 cases of PD patients from inpatient and outpatient in our hospital department of
Internal Medicine from March 2012 to March 2014 (the case group) were studied, and 50 cases of healthy were selected as control;
Homocysteine, folic acid and vitamin B12 levels between the two groups were compared and correlation between homocysteine , folic
acid,vitamin B12, levodopa dose and PD patients score (UPDRS score) were analyzed.Results:The plasma homocysteine of the case
group was significantly higher than that of the control group (P<0.05), folic acid and vitamin B12 levels were lower than those of the
control group, the difference between the two groups were statistically significant (P<0.05); The case group were divided into two
subgroups according to plasma homocysteine levels, the high-level group(≥ 14 umol/L) and low-level groups(<14 umol/L), there was on
difference in levodopa dose, folic acid and vitamin B12 and UPDRS score between the two subgroups, (P>0.05). Correlation analysis
showed a negative correlation between homocysteine and folic acid, vitamin B12 and UPDRS score (r=-0.545, -0.337, =-0.233, P=0.001,
0.009, 0.013), and a positive correlation with levodopa dose (r=0.518, P=0.001).Conclusion:Levodopa could elevate blood levels of
homocysteine, and reduce the amount of folic acid, vitamin B12 in treatment of PD, so it is necessary to enhance the folic acid, vitamin B12
and other nutritional support clinically. |
