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目的：观察儿童使用不同剂量的多乐氟氟化钠护齿剂(Duraphat)对其尿氟浓度的影响，为Duraphat 应用于群防群治提供理论依据。方法：采用氟离子选择电极法，将53 名3～4 岁儿童按班别分成三组，分别使用0.2 mL 及0.05 mL Duraphat涂布儿童牙齿，检测涂氟前和涂氟后1、2、3 d的尿氟浓度，并进行组内和组间比较。结果：各组使用Duraphat后尿氟浓度逐渐增加，涂氟后2 h开始与涂氟前比较差异均有统计学意义(P<0.05)，涂氟后3~4 h尿氟浓度达到高峰，至21 h后与涂氟前比较差异无统计学意义(P>0. 05)；3岁0.2 mL 组与0.05 mL 组在涂氟后2~4 h的尿氟浓度比较差异有显著性(P<0.05)，其他时间比较均无显著性差异(P>0.05)； 0.05 mL3 岁组与4 岁组比较尿氟浓度无明显差别(P>0.05)；3 岁初次用氟组和4 岁多次用氟组涂氟前尿氟无显著差异(P>0.05)。结论：儿童口腔局部用氟对其尿氟浓度有影响，随局部用氟剂量的增加而增加；年龄对儿童尿氟浓度无明显影响；Duraphat在体内无远期氟蓄积，在一定剂量内使用Duraphat可起到较好的防龋效果。

英文摘要:

Objective:To observe the impact of topical fluoridization with different doses of Duraphat on urinary fluoride levels of preschoolers, and provide theoretical basis for the application of topical fluoridization with Duraphat on mass prevention and treatment.Methods:53 children aged 3 and 4 years old were divided into 3 groups, 0.2 mL and 0.05 mL duraphat were varnished on their teeth respectively. The urinary fluoride concentration was accessed every day until the third day before and after varnishing. Fluoride concentration was determined with a potentiometric method using an ion selective electrode, comparisons were made within groups and among the groups.Results:The urinary fluoride levels gradually increased after using duraphat in different groups. Compared with the baseline, there were significant differences in the urinary fluoride level 2 h after topical fluoridization with Duraphat (P<0.05), which reached peak 3 to 4 h after topical fluoridization with Duraphat, no statistic difference was found 21 h after topical fluoridization with Duraphat(P>0.05). The urinary fluoride levels of the groups aged 3 receiving 0.2 mL with 0.05 mL duraphat had significant differences 2 to 4 h after topical fluoridization with Duraphat(P<0.05), but no significant difference was observed at other time points(P>0.05). There was also no obvious significance in the urinary fluoride levels among the groups aged 3 and 4 years old receiving 0.05 mL duraphat(P>0. 05), the 3-years old used duraphat once while the 4-year old used several times (P>0.05).Conclusion:Topial application of duraphat influenced the urinary fluoride level of children in a dose dependent manner. The age of children had no influence on the urinary fluoride. There was no fluoride retention in the body in the long term, topical fluoridization with certain dosage of Duraphat made the benefit on the caries prevention.

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