| 刘丽娟 赖雁威 李慧云 梁伟 胡会英.肝移植患者他克莫司谷血药浓度监测意义和临床个体化用药调节[J].现代生物医学进展英文版,2015,15(12):2281-2285. |
| 肝移植患者他克莫司谷血药浓度监测意义和临床个体化用药调节 |
| The Significance of Tacrolimus Blood Concentration Monitoring and ClinicalIndividualized Medication for Liver Transplantation Patients |
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| DOI： |
| 中文关键词: 肝移植 药物谷浓度 他克莫司 |
| 英文关键词: Liver transplantation The concentration of drug valley Tacrolimus |
| 基金项目:深圳市科技创新委员会立项项目（JCYJ20140415162338816） |
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| 中文摘要: |
| 目的：探讨移植术后监测他克莫司血药浓度意义和临床药物剂量个体化调节方法。方法：70 例肝移植患者术后采用口服他
克莫司，每天两次的用药方案，分别在移植后1 周和3 周监测血液中他克莫司浓度以及外周血单核细胞中钙调磷酸酶活性。结
果：移植3 周比1 周时他克莫司的清除率显著提高。每个采样时间的药物浓度都与0-12 h的浓时间曲线(AUC0-12)下方的面积呈
显著的正相关。钙调磷酸酶最低活性与0-12 h的钙调磷酸酶活性-时间曲线显著相关(r2>0.92)。结论：谷浓度监测是对成年生物配
体原位肝移植患者常规他克莫司用药剂量调整的最佳方法，同时监测患者钙调磷酸酶最低活性有助于估计患者在他克莫司用药
间隔期的免疫状况。 |
| 英文摘要: |
| Objective:To investigate the significance of tacrolimus blood concentration monitoring and clinical drug individual
dosage adjustment method.Methods:70 cases of liver transplantation patients had administration of tacrolimus two times daily after
transplantation. Their blood concentration of tacrolimus and calcineurin activity in PBMC were monitored respectively at one week and
three weeks after transplantation.Results:Acrolimus clearance rate increased significantly at three weeks compared to that at one week
after transplantation. The drug concentration of each sampling time point was positively related to the area under the concentration-time
curve of 0-12h (AUC0-12). A significant correlation was also found between the lowest calcineurin activity and 0-12 h calcineurin
activity time curves (r2>0.92).Conclusion:Concentration monitoring is the best method for adult patients with LDLT in conventional
tacrolimus dosage adjustment. Simultaneous monitoring of calcineurin activity in patients with the lowest is helpful in estimating the
immune status of patients in the tacrolimus dosing interval period. |
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