| 邓晓杨 赵锦秀 徐蕾 朱晓莺.Eotaxin-1 在浆液性卵巢癌组织中的表达及临床意义研究[J].现代生物医学进展英文版,2015,15(12):2242-2244. |
| Eotaxin-1 在浆液性卵巢癌组织中的表达及临床意义研究 |
| The Expression and Clinical Significance of Eotaxin-1 in Human SerousOvarian Cancer |
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| DOI： |
| 中文关键词: Eotaxin-1 浆液性卵巢癌 临床意义 |
| 英文关键词: Eotaxin-1 Serous ovarian cancer Clinical significance |
| 基金项目: |
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| 中文摘要: |
| 目的：研究嗜酸性粒细胞趋化因子1（Eotaxin-1）在浆液性卵巢癌组织中的表达及临床病理意义。方法：收集2013 年4 月至
2014 年5 月于我院妇产科手术切除的60 例浆液性卵巢癌及对应癌旁组织，采用免疫组织化学染色检测Eotaxin-1 表达，分析
Eotaxin-1 蛋白与肿瘤临床病理资料之间的相关性。结果：浆液性卵巢癌组织中Eotaxin-1 蛋白表达水平较对应癌旁组织显著升高
（P<0.05），浆液性卵巢癌组织中高表达Eotaxin-1 蛋白与恶性组织病理分级、淋巴结转移及高TNM分期呈显著正相关（P<0.05）。
结论：Eotaxin-1 蛋白在浆液性卵巢癌组织中表达上调，并与肿瘤恶性临床病理特征有关；Eotaxin-1 可能成为浆液性卵巢癌早期诊
断的重要标志物和生物靶向治疗的有效靶点之一，具有广阔的临床应用前景。 |
| 英文摘要: |
| Objective:To investigate the expression and clinical significance of Eotaxin-1 in human serous ovarian cancer.Methods:Immunohistochemistry (IHC) was applied to detect the protein expression of Eotaxin-1 in erous ovarian cancer (n=60) in
comparison to the corresponding tumor-adjacent normal tissues. Pearson chi-square test was used to analyze the relationship between the
Eotaxin-1 expression and clinical features.Results:The protein expression level of Eotaxin-1 in serous ovarian cancer tissues was
significantly higher than in adjacent normal tissues (P<0.05). The positive expression of Eotaxin-1 protein was also associated with
malignant tissue pathologic grades, lymphatic metastasis and advanced TNMstage (P<0.05).Conclusion:The expression of Eotaxin-1 in
serous ovarian cancer tissues was significantly higher than in tumor-adjacent normal tissues, and associated with tumor malignant
clinicopathological features Eotaxin-1 may become a new diagnosed marker and effective therapeutic target. |
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