| 周燊1 程亚涛1 王鹏龙1 张宇忠3 喻平2 侯桂萍2 井立萍2△ 雷海民1△." 一枝好" 育发液促进毛发生长及机制探讨[J].现代生物医学进展英文版,2015,15(12):2230-2233. |
| " 一枝好" 育发液促进毛发生长及机制探讨 |
| Research on the Promoting Effects of "Yizhihao" on Hair Growth in Mice |
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| DOI： |
| 中文关键词: "一枝好" 育发液 毛发生长 毛囊 人脐静脉血管内皮细胞 |
| 英文关键词: Xinjiang Uygur traditional Chinese herbal formulation "Yizhihao" Hair growth Hair follicle HUVECs |
| 基金项目:新疆维吾尔科技支疆项目（2013911011）；北京中医药大学创新团队项目（2011-CXTD-15） |
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| 中文摘要: |
| 目的：考察利用新疆维吾尔族传统药物研制成的" 一枝好"育发液促进毛发生长的效果，并探讨其可能的作用机制。方法：
采用硫化钠溶液建立昆明小鼠化学性脱发实验模型，将30 只昆明小鼠随机分为实验组、阳性对照组（章光101 育发剂）、空白对
照组，以毛发评分、毛长、毛重以及毛囊数为指标，考察小鼠新生毛发生长情况。对脱毛后21 天的脱毛区皮肤毛长、毛重、毛囊数
进行测量和统计分析。并利用MTT 法初步探讨" 一枝好"育发液对人脐静脉血管内皮细胞（HUVEC）增殖的影响。结果：实验组
脱毛区体毛生长评分及毛长，与空白对照组差异显著，并且略高于阳性对照组。对小鼠毛重与毛囊数的统计结果显示，与空白对
照组和阳性对照组相比，实验组均有显著性差异（P＜0.01，P＜0.001）。" 一枝好" 育发液能够促进人脐静脉血管内皮细胞
（HUVEC）增殖。结论：利用新疆维吾尔族传统药物研制成的" 一枝好" 育发液，能够显著促进小鼠毛发生长，初步推断其作用机
制与促进毛囊生长和促进血管内皮细胞增殖有关。 |
| 英文摘要: |
| Objective:To study the effects of Xinjiang Uygur traditional Chinese herbal preparation "Yizhihao" on hair growth in
mice, and to investigate its possible mechanism.Methods:Kun Ming mice were chosen as experimental animals. The 30 mice were
randomly divided into test group, normal control group and positive control group. The hair growth condition in 21 days was observed, as
well as the hair length and weight of each group. MTT assay was used to investigate the proliferation effects on human umbilical vein
vascular endothelial cells (HUVECs) of the aqueous extract of "Yizhihao".Results:Compared with the normal control group, the hair
length, weight and the number of hair follicles showed great significant difference (P<0.01,P<0.001). Compared with that in the positive
control group, the hair weight was higher and the number of hair follicles was more in the test group. "Yizhihao" could promote the
growth and proliferation of HUVECs significantly.Conclusion:Xinjiang Uygur traditional Chinese herbal formulation "Yizhihao" can
significantly promote hair growth in mice and its possible mechanismis to promote the growth of hair follicles and HUVECs. |
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